Publications

2023

Mol Ther Methods Clin Dev. 2023 Mar 21st, Online ahead of print. doi: 10.1016/j.omtm.2023.03.009
Channelrhodopsin fluorescent tag replacement for clinical translation of optogenetic hearing restoration
Zerche M, Wrobel C, Kusch K, Moser T, Mager T

BioRxiv. 2023 March 10th. doi: 10.1101/2022.08.03.502284
Visualizing proteins by expansion microscopy
Shaib AH, Chouaib AA, Chowdhury R, Mihaylov D, Zhang C, Imani V, Georgiev SV, Mougios N, Monga M, Reshetniak S, Mimoso T, Chen H, Fatehbasharzad P, Crzan D, Saal K-A, Alawar N, Eilts J, Kang J, Alvarez L, Trenkwalder C, Mollenhauer B, Outeiro TF, Köster S, Preobraschenski J, Becherer U, Moser T, Boyden ES, Aricescu AR, Sauer M, Opazo F, Rizzoli SO

Eur J Hum Genet. 2023 Jan 24th, Online ahead of print. doi: 10.1038/s41431-023-01285-0
An encounter with the mild side of LARS2-associated Perrault syndrome and its implications on the diagnostic odyssey
Vona B

Brain Stimul. 2023 Jan 23rd, Epub ahead of print. doi: 10.1016/j.brs.2023.01.1671
Graded optogenetic activation of the auditory pathway for hearing restorations
Mittring A, Moser T, Huet A

Frontiers in Neuroscience. 2023 Jan 23rd, 17:1105562. doi: 10.3389/fnins.2023.1105562
Patient perspectives on the need for improved hearing rehabilitation: A qualitative survey study of German cochlear implant users
Hunniford V, Kühler R, Wolf B, Daniel Keppeler D, Strenzke N, Moser T

GMS Zeitschrift für Audiologie - Audiological Acoustics. 2023 Jan 20th, Doc01. doi: 10.3205/zaud000027
Mit Lichtstrahlen das Gehör wiederherstellen - Restoring hearing with light
Moser T

Int J Mol Sci. 2023 Jan 18th, 24:1874. doi: 10.3390/ijms24031874
Not to miss: intronic variants, treatment, and review of the phenotypic spectrum in VPS13D-related disorder
Pauly MG, Brüggemann N, Efthymiou S, Grözinger A, Diaw SH, Chelban V, Turchetti V, Vona B, Tadic V, Houlden H, Münchau A, Lohmann K

BioRxiv. 2023 January 9th. doi: 10.1101/2022.12.19.521049
Age-dependent structural reorganization of utricular ribbon synapses
Wichmann C, Michanski S, Henneck T, Mukhopadhyay M, Steyer AM, Gonzalez PA, Grewe K, Ilgen P, Gültas M, Fornasiero EF, Jakobs S, Möbius W, Vogl C, Pangršič T, Rizzoli S

BioRxiv. 2023 January 7th. doi: 10.1101/2023.01.04.522823
Flotillin-Associated rhodopsin (FArhodopsin), a widespread paralog of proteorhodopsin in aquatic bacteria with streamlined genomes
Haro-Moreno JM, López-Pérez M, Alekseev A, Podoliak E, Kovalev K, Gordeliy V, Stepanauskas R, Rodriguez-Valera F

2022

Analytical Chemistry. 2022 December 27th, 94(51):17751-17756. doi: 10.1021/acs.analchem.2c00494
Mono- and intralink filter (Mi-filter) to reduce false identifications in cross-linking mass spectrometry data
Chen X, Sailer C, Kammer KM, Fürsch J, Eisele MR, Sakata E, Pellarin R, Stengel F

eLife. 2022 December 23rd, 11:e79494. doi: 10.7554/eLife.79494
Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses
Chakrabarti R, Jaime Tobon LM, Slitin L, Redondo-Canales M, Hoch G, Slashcheva M, Fritsch E, Bodensiek K, Özcete ÖD, Gültas M, Michanski S, Opazo F, Neef J, Pangrsic T, Moser T, Wichmann C

Materials (Basel). 2022 December 22nd, 16(1):106. doi: 10.3390/ma16010106
On the fabrication and characterization of polymer-based waveguide probes for use in future optical cochlear implants
Helke C, Reinhardt M, Arnold M, Schwenzer F, Haase M, Wachs M, Goßler C, Götz J, Keppeler D, Wolf B, Schaeper J, Salditt T, Moser T, Schwarz UT, Reuter D

BioRxiv. 2022 December 16th. doi: 10.1101/2022.12.15.520589
Piccolino regulates the architecture of the ribbon at cochlear inner hair cell synapses
Michanski S, Kapoor R, Steyer AM, Möbius W, Früholz I, Ackermann F, Gültas M, Garner CC, Hamra FK, Neef J, Strenzke N, Moser T, Wichmann C

Frontiers in Psychology. 2022 November 29th, 13:1047242. doi: 10.3389/fpsyg.2022.1047242
Group-based, autonomous, individualized training and testing of long-tailed macaques (Macaca fascicularis) in their home enclosure to a visuo-acoustic discrimination task
Cabrera-Moreno J, Jeanson L, Jeschke M, Calapai A

Frontiers in Cell and Developmental Biology. 2022 November 28th, 10:987691. doi: 10.3389/fcell.2022.987691
Monoallelic loss of the F-actin-binding protein radixin facilitates startle reactivity and pre-pulse inhibition in mice
Hausrat TJ, Vogl C, Neef J, Schweizer MC, Yee BK, Strenzke N, Kneussel M

BioRxiv. 2022 November 27th. doi: 10.1101/2022.11.27.518035
Optical measurement of glutamate release robustly reports short-term plasticity at a fast central synapse
Hain PJH, Moser T

Nature. 2022 November 23th, 611:827-834. doi: 10.1038/s41586-022-05472-9
Regulation of the mammalian-brain V-ATPase through ultraslow mode-switching
Kosmidis E, Shuttle CG, Preobraschenski J, Ganzella M, Johnson PJ, Veshaguri S, Holmkvist J, Møller MP, Marantos O, Marcoline F, Grabe M, Pedersen JL, Jahn R, Stamou D

Human Molecular Genetics. 2022 October 27th; ddac267. doi: 10.1093/hmg/ddac267
A mutation in ATP11A causes autosomal-dominant auditory neuropathy type 2
Chepurwar S, von Loh SM, Wigger DC, Neef J, Frommolt P, Beutner D, Lang-Roth R, Kubisch C, Strenzke N, Volk AE

Developmental Dynamics. 2022 October 25th. doi: 10.1002/dvdy.548. Online ahead of print
Cochlear hair cell innervation is dependent on a modulatory function of semaphorin-3A
Cantu-Guerra HL, Papazain MR, Gorsky AL, Alekos NS, Caccavano A, Karagulyan N, Neef J, Vicini S, Moser T, Coate TM

bioRxiv. 2022 October 20th. doi: 10.1101/2022.10.19.512823
Bridging the gap between presynaptic hair cell function and neural sound encoding
Jaime Tobón LM, Moser T

International Journal of Molecular Sciences. 2022 September 14th; 23(18):10673. doi: 10.3390/ijms231810673
Skeletal class III malocclusion is associated with ADAMTS2 variants and reduced expression in a familial case
Yao S, Zhou X, Vona B, Fan L, Zhang C, Li D, Yuan H, Du Y, Ma L, Pan Y

bioRxiv. 2022 September 6th. doi: 10.1101/2022.09.05.506618
Graded optogenetic activation of the auditory pathway for neural network analysis and hearing restoration
Mittring A, Huet AT, Moser T

EMBO Molecular Medicine. 2022 August 8th; 14(8):e15798. doi: 10.15252/emmm.202215798
Is there an unmet medical need for improved hearing restoration?
Wolf BJ, Kusch K, Hunniford V, Vona B, Kühler R, Keppeler D, Strenzke N, Moser T

bioRxiv. 2022 August 5th. doi: 10.1101/2022.08.03.502284
Expansion microscopy at one nanometer resolution
Shaib AH, Chouaib AA, Imani V, Chowdhury R, Georgiev SV, Mougios N, Mehar M, Reshetniak S, Mihaylov D, Chen H, Fatehbasharzad P, Crzan D, Saal K-A, Trenkwalder C, Mollenhauer B, Outiero TF, Preobraschenki J, Becherer U, Moser T, Boyden ES, Aricescu AR, Sauer M, Opazo F, Rizzoli SO

Annals of Clinical and Translational Neurology. 2022 July 23rd, 9(9):1465-1474. doi: 10.1002/acn3.51633.
GGPS1-associated muscular dystrophy with and without hearing loss
Kaiyrzhanov R, Perry L, Rocca C, Zaki MS, Hosny H, Araujo Martins Moreno C, Phadke R, Zaharieva I, Camelo Gontijo C, Beetz C, Pini V, Movahedinia M, Zanoteli E, DiTroia S, Vuillaumier-Barrot S, Isapof A, Mehrjardi MYV, Ghasemi N, Sarkozy A, Muntoni F, Whalen S, Vona B, Houlden H, Maroofian R

Methods in Molecular Biology. 2022 July 21st, 2501:277-288. doi: 10.1007/978-1-0716-2329-9_13
Electrophysiological characterization of microbial rhodopsins by patch-clamp experiments
Mager T

Human Mutation. 2022 July 21st, 43(10):1472-1489. doi: 10.1002/humu.24435
Biallelic variants in WARS1 cause a highly variable neurodevelopmental syndrome and implicate a critical exon for normal auditory function
Lin SJ, Vona B, Porter HM, Izadi M, Huang K, Lacassie Y, Rosenfeld JA, Khan S, Petree C, Ali TA, Muhammad N, Khan SA, Muhammad N, Liu P, Haymon ML, Rüschendorf F, Kong IK, Schnapp L, Shur N, Chorich L, Layman L, Haaf T, Pourkarimi E, Kim HG, Varshney GK

Human Mutation. 2022 July 21st, 43(10):1454-1471. doi: 10.1002/humu.24430
WARS1 and SARS1: two tRNA synthetases implicated in autosomal recessive microcephaly
Bögershausen N, Krawczyk HE, Jamra RA, Lin S-L, Yigit G, Hüning I, Molins Polo A, Vona B, Huang K, Schmidt J, Altmüller J, Luppe J, Platzer K, Dörgeloh BB, Busche A, Biskup S, Mendes MI, Smith DEC, Salomons GS, Zibat A, Bültmann E, Nürnberg P, Spielmann M, Lemke JR, LI Y, Zenker M, Varshney GK, Hillen HS, Kratz Christian P, Wollnik B

IEEE Spectrum. Online, 2022 July 18th.
Restoring hearing with beams of light
Moser T

Science Advances. 2022 July 15th, 8(28):eabl7560. doi: 10.1126/sciadv.abl7560
Resolving the molecular architecture of the photoreceptor active zone with 3D-MINFLUX
Grabner CP, Jansen I, Neef J, Weihs T, Schmidt R, Riedel D, Wurm CA, Moser T

Clinical and Translational Discovery. 2022 July 7th. doi: 10.1002/ctd2.102. Online ahead of print, 2022 July 7th
Whole genome sequencing for newborns—The devil is in the details
Vona B

Computational and Structural Biotechnology Journal. 2022 July 6th.
Model-based prediction of optogenetic sound encoding in the human cochlea by future optical cochlear implants
Khurana L, Keppeler D, Jablonski L, Moser T

Molecular and Cellular Neuroscience. 2022 June 7th, 103749. doi: 10.1016/j.mcn.2022.103749
Synaptic transmission at the vestibular hair cells of amniotes
Mukhopadhyaya M, Pangrsic T

Journal of the American Chemical Society. 2022 June 1st, 144(21):9229-9239. doi: 10.1021/jacs.1c12314
Fast photoswitchable molecular prosthetics control neuronal activity in the cochlea
Garrido-Charles A, Huet A, Matera C, Thirumalai A, Hernondo J, Liebaria A, Moser T, Gorostiza P

American Journal of Human Genetics. 2022 May 12th, S0002-9297(22)00158-6. doi: 10.1016/j.ajhg.2022.04.010
Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss
Trpchevska N, Freidin MB, Broer L, Oosterloo BC, Yao S, Zhou Y, Vona B, Bishop C, Bizaki-Vallaskangas A, Canlon B, Castellana F, Chasman DI, Cherny S, Christensen K, Concas MP, Correa A, Elkon R, Estonian Biobank Research Team, Mengel-From J, Gao Y, Giersch ABS, Girotto G, Gudjonsson A, Gudnason V, Heard-Costa NL, Hertzano R, Hjelmborg JVB, Hjerling-Leffler J, Hoffman HJ, Kaprio J, Kettunen J, Krebs K, Kähler AK, Lallemend F. Launer LJ, Lee IM, Leonard H, LI CM, Lowenheim H, Magnusson PKE, van Meurs J, Milani L, Morton CC, Mäkitie A, Nalls MA, Nardone GG, Nygaard M, Palviainen T, Pratt S, Quaranta N, Rämö J, Saarentaus E, Sardone R, Satizabal Barrera CL, Schweinfurth JM, Seshadri S, Shiroma E, Shulam E, Simonsick E, Spankovich C, Tropitzsch A, Lauschke VM, Sullivan PF, Goedegebure A, Cederroth CT, Williams FMK, Nagtegaal AP

Journal of the European Academy of Dermatology and Venereology. 2022 May 11th, doi: 10.1111/jdv.18207
Biallelic KITLG variants lead to a distinct spectrum of hypomelanosis and sensorineural hearing loss
Vona B, Schwartzbaum DA, Rodriguez AA, Lewis SS, Toosi MB, Radhakrishnan P, Bozan N, Akin R, Doosti M, Manju R, Duman D, Sineni CJ, Nampoothriti S, Karimiani EG, Houlden H, Bademci G, Tekin M, Girisha KM, Maroofian R, Douzgou S

bioRxiv. 2022 May 10th.
Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses
Chakrabarti R, Jaime Tobón L M, Slitin L, Redondo-Canales, M, Hoch G, Slashcheva M, Fritsch E, Bodensiek K, Özçete Ö D, Gültas M, Michanski S, Opazo F, Neef J, Pangršič T, Moser T, Wichmann C

Life Science Alliance. 2022 May 5th, 5(8):e202101338. doi: 10.26508/lsa.202101338
Analyzing efficacy, stability and safety of AAV-mediated optogenetic hearing restoration in mice
Bali B, Gruber-Dujardin E, Kusch K, Rankovic V, Moser T

Neuron. 2022 May 4th, 110(9):1483-1497.e7. doi: 10.1016/j.neuron.2022.02.008
Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3
Upmanyu N, Jin J, Emde HV, Ganzella M, Bösche L, Malviya VN, Zhuleku E, Politi AZ, Ninov M, Silbern I, Leutenegger M, Urlaub H, Riedel D, Preobraschenski J, Milosevic I, Hell SW, Jahn R, Sambandan S

Nature Communications. 2022 March 28th, 13:1648. doi: 10.1038/s41467-022-29185-9
Flexible auditory training, psychophysics, and enrichment of common marmosets with an automated, touchscreen-based system
Calapai A, Cabrera-Moreno J, Moser T, Jeschke M

Human Genetics. 2022 March 12th, 141(3-4):431-444. doi: 10.1007/s00439-022-02444-x
Autosomal dominant non-syndromic hearing loss maps to DFNA33 (13q34) and co-segregates with splice and frameshift variants in ATP11A, a phospholipid flippase gene
Pater JA, Penney C, O'Rielly DD, Griffin A, Kamal L, Brownstein Z, Vona B, Vinkler C, Shohat M, Barel O, French CR, Singh S, Werdyani S, Burt T, Abdelfatah N, Houston J, Doucette LP, Squires J, Glaser F, Roslin NM, Vincent D, Marquis P, Woodland G, Benoukraf T, Hawkey-Noble A, Avraham KB, Stanton SG, Young TL

Molelcular and Cellular Neuroscience. 2022 March 11th, 120:103720. doi: 10.1016/j.mcn.2022.103720
Methods for multiscale structural and functional analysis of the mammalian cochlea
Vogl C, Neef J, Wichmann C

eLife. 2022 March 11th, doi: 10.7554/eLife.75523
Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5
Buscham T J, Eichel-Vogel M A, Steyer A M, Jahn O, Strenzke N, Dardawal R, Memhave R T, Siems S B, Müller C. Meschkat M, Sun T, Ruhwedel T, Möbius W, Krämer-Albers E-M, Boretius S, Nave K-A, Werne H B

Nature Communications. 2022 March 4th, 13:1163. doi: 10.1038/s41467-022-28720-y
White matter integrity requires continuous myelin synthesis at the inner tongue in mice
Meschkat M, Steyer A, Weil MT, Kusch K, Jahn O, Piepkorn L, Agüi-Gonzalez P, Phan N, Ruhwedel T, Sadowski B, Rizzoli S, Werner H, Ehrenreich H, Nave KA, Möbius W

Orphanet Journal of Rare Diseases. 2022 March 3rd, 17(1):97. doi: 10.1186/s13023-022-02244-6
Identification of three novel homozygous variants in COL9A3 causing autosomal recessive Stickler syndrome
Rad A, Najafi M, Suri F, Abedini S, Loum S, Karimiani EG, Daftarian N, Murphy D, Doosti M, Moghaddasi A, Ahmadieh H, Sabbaghi H, Rajati M, Hashemi N, Vona B, Schmidts M

HNO. 2022 March, 70:200–205. doi: 10.1007/s00106-021-01100-6
3-D-Druck-optimierte Anpassung eines Mittelgesichtsimplantats zur magnetgetragenen nasalen Epithesenversorgung
Wrobel C, Keppeler D, Meyer AC

Nature Communications. 2022 February 21st, 21;13(1):985. doi: 10.1038/s41467-022-28629-6
Multichannel optogenetics combined with laminar recordings for ultra-controlled neuronal interrogation
Eriksson D, Schneider A, Thirumalai A, Alyahyay M, de la Crompe B, Sharma K, Ruther P, Diester I

Molecular Diagnosis & Therapy. 2022 February 15th. doi: 10.1007/s40291-022-00578-2
The Road Traveled and Journey Ahead for the Genetics and Genomics of Tinnitus
Vona B

Nature Communications. 2022 February 11th, 13(1):838. doi: 10.1038/s41467-022-28186-y
Allosteric control of Ubp6 and the proteasome via a bidirectional switch
Hung KYS, Klumpe S, Eisele MR, Elsasser S, Tian G, Sun S, Moroco JA, Cheng TC, Joshi T, Seibel T, Van Dalen D, Feng XH, Lu Y, Ovaa H, Engen JR, Lee BH, Rudack T, Sakata E, Finley D

eLife., 2022 February 7th, 11:e72251.doi: 10.7554/eLife.72251
The Cl--channel TMEM16A is involved in the generation of cochlear Ca2+ waves and promotes the refinement of auditory brainstem networks in mice
Maul A, Huebner AK, Strenzke N, Moser T, Rübsamen R, Jovanovic S, Hübner CA

Journal of Neuroscience. 2022 January 20th, JN-RM-0216-21. doi: 10.1523/JNEUROSCI.0216-21.2022
Selective interruption of auditory interhemispheric crosstalk impairs discrimination learning of frequency-modulated tone direction but not gap detection and discrimination
Saldeitis K, Jeschke M, Michalek A, Henschke J, Wetzel W, Ohl F, Budinger E

Frontiers in Neural Circuits. 2022 January 5th.
Effects of cortical cooling on sound processing in auditory cortex and thalamus of awake marmosets
Jeschke M, Ohl FW, Wang X



2021

Laryngoscope Investig Otolaryngology. 2021 December 7th, 7(1):219-225. doi: 10.1002/lio2.714
Performance and self-perceived hearing impairment after cochlear implantation in Menière's disease
Wrobel C, Bevis NF, Klinge-Strahl A, Strenzke N, Beutner D

Physiological Reviews. 2021 November 2nd, 102: 269–318. doi: 10.1152/physrev.00039.2020
Heterogeneity of glutamatergic synapses: cellular mechanisms and network consequences
Wichmann C, Kuner T

eLife. 2021 October 7th, 10:e63844. doi: 10.7554/eLife.63844
The mammalian rod synaptic ribbon is essential for Cav channel facilitation and ultrafast synaptic vesicle fusion
Grabner CP, Moser T

Journal of Neuroscience. 2021 September 15th, 41 (37) 7742-7767. doi: 10.1523/JNEUROSCI.0586-21.2021
RIM-Binding Protein 2 organizes Ca2+ channel topography and regulates release probability and vesicle replenishment at a fast central synapse
Butola T, Alvanos T, Hintze A, Koppensteiner P, Kleindienst D, Shigemoto R, Wichmann C, Moser T

Journal of Cell Science. 2021 September 6th, jcs.258559. doi: 10.1242/jcs.258559
Tubular microdomains of Rab7-endosomes retrieve TrkA, a mechanism disrupted in Charcot-Marie-Tooth 2B
Markworth R, Dambeck V, Steinbeck LM, Koufali A, Bues B, Dankovich TM, Wichmann C, Burk K

Frontiers in Molecular Neuroscience, section Methods and Model Organisms. 2021 August 19th.
Cabp2-gene therapy restores inner hair cell calcium currents and improves hearing in a DFNB93 mouse model
Oestreicher O, Picher MM, Rankovic T, Moser T, Pangrsic T

Frontiers in Cellular Neuroscience. 2021 July 14th. doi: 10.3389/fncel.2021.677543
Otoferlin Is Required for Proper Synapse Maturation and for Maintenance of Inner and Outer Hair Cells in Mouse Models for DFNB9
Stalmann U,Franke A, Al-Moyed H, Strenzke N, Reisinger E

Frontiers in Neural Circuits. 2021 July 12th.
Laser-induced apoptosis of corticothalamic neurons in layer VI of auditory cortex impact on cortical frequency processing
Saldeitis K, Jeschke M, Budinger, E, Ohl FW, Happel MFK

bioRxiv. 2021 May 30th.
Resolving the molecular architecture of the photoreceptor active zone by MINFLUX nanoscopy
Grabner CP, Jansen I, Neef J, Weiss T, Schmidt R, Riedel D, Wurm CA, Moser T

EMBO Molecular Medicine. 2021 May 7th, e13391. doi: 10.15252/emmm.202013391
Utility of red-light ultrafast optogenetic stimulation of the auditory pathway
Bali B, Lopez de la Morena D, Mittring A, Mager T, Rankovic V, Huet AT, Moser T

PNAS. 2021 May 4th, 118 (18) e2014472118. doi: 10.1073/pnas.2014472118
Multiscale photonic imaging of the native and implanted cochlea
Keppeler D, Kampshoff C, Thirumalai A, Duque-Afonso CJ, Schaeper J, Quilitz T, Töpperwien M, Vogl C, Hessler R, Meyer A, Salditt T, Moser T

Frontiers in Molecular Neuroscience. 2021 March 23rd, doi: 10.3389/fnmol.2021.651935
RIM-binding proteins are required for normal sound-encoding at afferent inner hair cell synapses
Krinner S, Predoehl F, Burfeind D, Vogl C, Moser T

Frontiers in Molecular Neuroscience, 2021 March 11th, https://doi.org/10.3389/fnmol.2021.635897
Developing fast, red-light optogenetic stimulation of spiral ganglion neurons for future optical cochlear implants
Huet AT, Dombrowski T, Rankovic V, Thirumalai A, Moser T

iScience. 2021 March 8th, 24(4):102282. doi: 10.1016/j.isci.2021.102282
Ultrastructural maturation of the endbulb of Held active zones comparing wild-type and otoferlin-deficient mice
Hintze A, Gültas M, Semmelhack EA, Wichmann C

Biochimica et Biophysica Acta (BBA). 2021 March 1st. doi: 10.1016/j.bbapap.2020.140583
Molecular and cellular dynamics of the 26S proteasome
Sakata E, Eisele MR, Baumeister W

Frontiers in Molecular Neuroscience. 2021 January 7th, 13:253. doi: 10.3389/fnmol.2020.600051
Overloaded adeno-associated virus as a novel gene therapeutic tool for otoferlin-related deafness
Rankovic V, Vogl C, Dörje NM, Bahader I, Duque-Afonso CJ, Thirumalai A, Weber T, Kusch K, Strenzke N, Moser T

EBioMedicine. 2021 January 7th, Volume 63, 103171.
Understanding and Treating Paediatric Hearing Impairment
Wrobel C, Zafeiriou M-P, Moser T

Cell Reports, 2021 January 5th; 34(1):108551. doi: 10.1016/j.celrep.2020.108551
Electron Microscopic Reconstruction of Neural Circuitry in the Cochlea
Hua Y, Ding X, Wang H, Wang F, Lu Y, Neef J, Gao Y, Moser T, Wu H

Frontiers in Neuroscience. 2021 January 5th, 14:598406. doi: 10.3389/fnins.2020.598406
Acute and Long-Term Circuit-Level Effects in the Auditory Cortex After Sound Trauma
Jeschke M, Happel MFK, Tziridis K, Krauss P, Schilling A, Schulze H, Ohl FW



2020

Faculty Reviews. 2020 December 21st, 9:24. doi: 10.12703/r/9-24
Recent advances in cochlear hair cell nanophysiology: subcellular compartmentalization of electrical signaling in compact sensory cells
Effertz T, Moser T, Oliver D

EMBO Journal. 2020 December 21st, e106010. doi: 10.15252/embj.2020106010
A sensory cell diversifies its output by varying Ca2+ influx-release coupling among active zones
Özçete ÖD, Moser T

Life. 2020 December 18th, 10(12):360. doi: 10.3390/life10120360
Characterization of Sensorineural Hearing Loss in Children with Alport Syndrome
Boeckhaus J, Strenzke N, Storz C, Gross O

International Journal of Molecular Sciences. 2020 November 19th; 21(22), 8758. doi: 10.3390/ijms21228758
Molecular Assembly and Structural Plasticity of Sensory Ribbon Synapses—A Presynaptic Perspective
Voorn RA, Vogl C

Nature Communications 2020 Nov 11;11(1):5707. doi: 10.1038/s41467-020-19457-7
Viral rhodopsins 1 are an unique family of light-gated cation channels
Zabelski D, Alekseev A, Kovalev K, Rankovic V, Balandin T, Soloviov D, Bratanov D, Saveljeva E, Podolyak E, Vokov D, Vaganova S, Astashkin R, Chizov I, Yutin N, Rulev M, Popov A, Eria-Oliveria A-S, Rokitskay T, Mager T, Antonenko Y, Rosselli R, Armeev G, Shaitan K, Vivaudou M, Büldt G, Rogachev A, Rodriguez-Valera F, Kripchnikov M, Moser T, Offenhäuser A, Willbold D, Koonin E, Bamberg E, Gordeliy V

Nature Communications, 2020 Oct 30;11(1):5497. doi: 10.1038/s41467-020-19152-7
A role of oligodendrocytes in information processing
Moore S, Meschkat M, Ruhwedel T, Trevisiol A, Tzvetanova ID, Battefeld A, Kusch K, Kole MHP, Strenzke N, Möbius W, de Hoz L, Nave KA

Book chapter in: Ludwig van Beethoven: the Heard and the Unhearing, edited by Bernhard Richter, Wolfgang Holzgreve, Claudia Spahn, Herder, ISBN 978-3-451-38871-2, October 2020
How does hearing work?
Moser T

Methods in Molecular Biology 2021, 2020 Sep 01;2191:261-285. doi: 10.1007/978-1-0716-0830-2_16
Application of targeting-optimized Chronos for stimulation of the auditory pathway
Huet A, Rankovic V

Book chapter in: The Senses: A Comprehensive Reference, 2nd Edition, 2020 Sep 8, Book ISBN: 9780128054086
Presynaptic Physiology of Cochlear Inner Hair Cells
Moser T

Science Translational Medicine, 2020 Jul 22;Vol. 12, Issue 553, eabb8086. DOI: 10.1126/scitranslmed.abb8086
Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents
Keppeler D, Schwaerzle M, Harczos T, Jablonski L, Dieter A, Wolf B, Ayub S, Vogl C, Wrobel C, Hoch G, Abdellatif K, Jeschke M, Rankovic V, Paul O, Ruther P, Moser T
[abstract] [reprint] [full text]

EMBO Molecular Medicine, 2020 Jun 29;e12387. doi: 10.15252
μLED-based optical cochlear implants for spectrally selective activation of the auditory nerve
Dieter A, Klein E, Keppeler D, Jablonski L, Harczos T, Hoch G, Rankovic V, Paul O, Jeschke M, Ruther P, Moser T

Nature communications, June 25th 2020, doi.org/10.1038/s41467-020-17003-z
Macromolecular and electrical coupling between inner hair cells in the rodent cochlea
Jean P, Anttonen T, Michanski S, de Diego AMG, Steyer AM, Neef A, Oestreicher D, Kroll J, Nardis C, Pangršič T, Möbius W, Ashmore J, Wichmann C, Moser T

bioRxiv, May 2020, preprint
Hearing restoration by a low-weight power-efficient multichannel optogenetic cochlear implant system
Jablonski L, Harczos T, Wolf B, Hoch G, Dieter A, Hessler R, Ayub S, Ruther P, Moser T

Nanoscale, 2020 May 14;12(18):10226-10239. doi: 10.1039/d0nr00227e
Circumvention of common labelling artefacts using secondary nanobodies
Sograte Idrissi S, Schlichthärle T, Duque Afonso C, Alevra M, Strauss S, Moser T, Jungmann R, Rizzoli SO, Opazo F

Physiological Reviews, 2020 Jul 6, 100(4):1467-1525. doi: 10.1152/physrev.00035.2019
Emerging approaches for restoration of hearing and vision
Kleinlogel S, Vogl C, Jeschke M, Neef J, Moser T

EMBO Molecular Medicine, 2020 Mar 30. e11618, doi.10.15252/emmm.201911618
Towards the Optical Cochlear Implant: Optogenetic Approaches for Hearing Restoration
Dieter A, Keppeler D, Moser T

Biochemical and Biophysical Research Communications, 2020 Feb 4. pii: S0006-291X(20)30090-5. doi: 10.1016/j.bbrc.2019.12.126
Towards optogenetic approaches for hearing restoration
Moser T, Dieter A

Journal of Cell Science, 2020 Jan 22. pii: jcs.236737. doi: 10.1242/jcs.236737
AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells
Kroll J, Özcete Ö, Jung S, Maritzen T, Milosevic I, Wichmann C, Moser T



2019

The Journal of Neuroscience, 2019 Sep 16, 0028-19; doi: 10.1523/JNEUROSCI.0028-19.2019
β-secretase BACE1 is required for normal cochlear function
Dierich M, Hartmann S, Dietrich N, Moeser P, Brede F, Johnson Chacko L, Tziridis K, Schilling A, Krauss P, Hessler S, Karch S, Schrott-Fischer A, Blumer M, Birchmeier C, Oliver D, Moser T, Schulze H, Alzheimer C, Leitner M, Huth T

Physiological Reviews, 2019 Aug 2, doi: 10.1152/physrev.00026.2018. [Epub ahead of print]
Sensory processing at ribbon synapses in the retina and the cochlea
Moser T, Grabner C, Schmitz F

Journal of Neuroscience, 2019 Jul 3. 39(27):5284-5298; doi: 10.1523/JNEUROSCI.2728-18.2019
Pou4f1 defines a subgroup of Type I spiral ganglion neurons and is necessary for normal inner hair cell presynaptic Ca2+ signaling
Sherrill H, Jean P, Driver E, Sanders T, Fitzgerald T, Moser T, Kelley M

International Journal of Molecular Sciences, Apr 30, 2019, 20(9), 2147; doi: 10.3390/ijms20092147
Nanomachinery organizing release at neuronal and ribbon synapses
Chakrabarti R, Wichmann C

Nature Communications, 2019 Apr 29, 10 1962, doi: 10.1038/s41467-019-09980-7
Near physiological spectral selectivity of cochlear optogenetics
Dieter A, Duque Afonso CJ, Rankovic V, Jeschke M, Moser T

PNAS, 2019 Apr 11. pii: 201818358. doi: 10.1073/pnas.1818358116
Intrinsic planar polarity mechanisms influence the position-dependent regulation of synapse properties in inner hair cells
Jean P, Demet Özçete Ö, Tarchini B, Moser T

PNAS, 2019 Mar 13. pii: 201812029. doi: 10.1073/pnas.1812029116Access the recommendation on F1000Prime
Mapping developmental maturation of inner hair cell ribbon synapses in the apical mouse cochlea
Michanski S, Smaluch K, Steyer AM, Chakrabarti R, Setz C, Oestreicher D, Fischer C, Möbius W, Moser T, Vogl C, Wichmann C

EMBO J., 2019 Mar 1;38(5). pii: e100116. doi: 10.15252/embj.2018100116
Endophilin-A regulates presynaptic Ca2+ influx and synaptic vesicle recycling in auditory hair cells
Kroll J, Jaime Tobón LM, Vogl C, Neef J, Kondratiuk I, König M, Strenzke N, Wichmann C, Milosevic I, Moser T

Frontiers in Molecular Neuroscience, 2019 Jan 9;11:492. doi: 10.3389/fnmol.2018.00492
Disruption of otoferlin alters the mode of exocytosis at the mouse inner hair cell ribbon synapse
Takago H, Oshima-Takago T, Moser T



2018

EMBO Molecular Medicine, December 12th, 2018, doi: 10.15252/emmm.201809396
A dual-AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock-out mice
Al-Moyed H, Cepeda AP, Jung S, Moser T, Kügler S, Reisinger E

EMBO Journal, 05 Nov 2018, doi: 10.15252/embj.201899649
Ultrafast optogenetic stimulation of the auditory pathway by targeting-optimized Chronos
Keppeler D, Martins Merino R, Lopez de la Morena D, Bali B, Huet AT, Gehrt A, Wrobel C, Subramanian S, Dombrowski T, Wolf F, Rankovic V, Neef A, Moser T

PNAS, October 19th, 2018, 2018-11814R, doi: 10.1073/pnas.1811814115
Individual synaptic vesicles mediate stimulated exocytosis from cochlear inner hair cells
Grabner C, Moser T

Frontiers in Cellular Neuroscience , October 17th, 2018, doi.org:10.3389/fncel.2018.00364
Ca2+ regulates the kinetics of synaptic vesicle fusion at the afferent inner hair cell synapse
Huang C-H, Moser T

Cold Spring Harbor Laboratory Press, October 15th, 2018, a033225 doi: 10.1101/cshperspect.a033225
Toward the optical cochlear implant
Dombrowski T, Rankovic V, Moser T

EMBO Reports 10 Sep 2018: e44937; doi: 10.15252/embr.201744937
Vesicle sub-pool organization at inner hair cell ribbon synapses
Chakrabarti R, Michanski S, Wichmann C

Frontiers in Physiology, 08 Oct 2018, doi.org/10.3389/fphys.2018.01227
Axial Tubule Junctions Activate Atrial Ca2+ Release across Species
Brandenburg S, Pawlowitz J, Fakuade FE, Kownatzki-Danger D, Kohl T, Mitronova GY, ScardigliM, Neef J, Schmidt C, Wiedmann F, Pavone F, Sacconi L, Kutschka I, Sossalla ST, Moser T, Voigt N, Lehnart SE

Physiological Reviews 01 Aug 2018: Vol. 98, Issue 4, DOI: 10.1152/physrev.00030.2017
Voltage-Gated Calcium Channels: Key Players in Sensory Coding in the Retina and the Inner Ear
Pangrsic T, Singer JH, Koschak A

Journal of Cell Biology 06 Sep 2018: Vol. 217, no. 11
Cytomatrix proteins CAST and ELKS regulate retinal photoreceptor development and maintenance
Hagiwara A, Kitahara Y, Grabner CP, Vogl C, Abe M, Kitta R, Ohta K, Nakamura K, Sakimura K, Moser T, Nishi A, Othsuka T

Science Translational Medicine 11 Jul 2018: Vol. 10, Issue 449, eaao0540 DOI: 10.1126/scitranslmed.aao0540
Optogenetic stimulation of cochlear neurons activates the auditory pathway and restores auditory-driven behavior in deaf adult gerbils
Wrobel C, Dieter A, Huet A, Keppeler D, Duque-Afonso CJ, Vogl C, Hoch G, Jeschke M, Moser T

Hear Res. 2018 Jul;364:48-58. doi: 10.1016/j.heares.2018.04.001
Functions of CaBP1 and CaBP2 in the peripheral auditory system
Yang T, Hu N, Pangršič T, Green S, Hansen M, Lee A

Sci Rep. 2018 Jun 21;8(1):9422. doi: 10.1038/s41598-018-27456-4
A convenient protocol for generating giant unilamellar vesicles containing SNARE proteins using electroformation
Witkowska A, Jablonski L, Jahn R

Nature Communications 2018 May 1 doi:10.1038/s41467-018-04146-3
High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics
Mager T, Lopez de la Morena D, Senn V, Schlotte J, D´Errico A, Feldbauer K, Wrobel C, Jung S, Bodensiek K, Rankovic V, Browne L, Huet A, Jüttner J, Wood P, Letzkus J, Moser T, Bamberg E

Nature Communications 2018 Aug 29;9(1):3509. doi: 10.1038/s41467-018-05766-5
High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis
Xu X,Tan X, Tampe B, Wilhelmi T, Hulshoff M, Saito S, Moser T, Kalluri R, Hasenfuss G, Zeisberg E, Zeisberg M

Laryngo-Rhino-Otol 2018 Mar 22. 97(S 01): S1-S9
Molekulares Verstehen des Hörens – Was ändert sich für den Patienten?
Moser T

Scientific Reports 8 March 21, 2018.
Propagation-based phase-contrast x-ray tomography of cochlea using a compact synchrotron source
Töpperwien M, Gradl R, Keppeler D, Vassholz M, Meyer A, Hessler R, Achterhold K, Gleich B, Dierolf M, Pfeiffer F, Moser T, Salditt T

Nat Comm. 2018 Jan 18 9, 290. doi:10.1038/s41467-017-02612-y
Quantitative optical nanophysiology of Ca2+-signaling at inner hair cell active zones.
Neef J, Ohn TL, Urban NT, Frank T, Jean P, Hell SW, Willig KI, Moser T.

eLife 2018 Jan 12; 7:e29275 doi: 10.7554/eLife.29275 Access the recommendation on F1000Prime
The synaptic ribbon is critical for sound encoding at high rates and with temporal precision.
Jean P, Lopez de la Morena D, Michanski S, Jaime Tobón LM, Chakrabarti R, Picher MM, Neef J, Jung SY, Gültas M, Maxeiner S, Neef A, Wichmann C, Strenzke N, Grabner C, Moser T

Hum Genet. 2018 Jan 5. https://doi.org/10.1007/s00439-017-1862-z
The CAPOS mutation in ATP1A3 alters Na/K-ATPase function and results in auditory neuropathy which has implications for management.
Tranebjærg L, Strenzke N, Lindholm S, Rendtorff ND, Poulsen H, Khandelia H, Kopec W, Brünnich Lyngbye TJ, Hamel C, Delettre C, Bocqet B, Bille M, Owen HH, Bek T, Jensen H, Østergaard K, Möller C, Luxon L, Carr L, Wilson L, Rajput K, Sirimanna T, Harrop-Griffiths K, Rahman S, Vona B, Doll J, Haaf T, Bartsch O, Rosewich H, Moser T, Bitner-Glindzicz M

EMBO J 2018 Jan 4; 37(1): 139–159, published online 2017 Nov 16. e201695709, doi: 10.15252/embj.201695709
Glyoxal as an alternative to PFA in immunostainings and nanoscopy.
Richter KN, Revelo NH, Seitz KJ, Helm MS, Sarkar D, Saleeb R, D’Este E, Eberle J, Wagner E, Vogl C, Lazaro DF, Richter F, Vegara JC, Coceano G, Boyden E, Duncan R, Hell SW, Lauterbach M, Lehnart SE, Moser T, Outeiro T, Rehling P, Schwappach B, Testa I, Zapiec B, Rizzoli SO.



2017

Front Cell Neurosci 2017 Oct 11th; doi: 10.3389/fncel.2017.00334
RIM-binding protein 2 promotes a large number of CaV1.3 Ca2+-channels and contributes to fast synaptic vesicle replenishment at hair cell active zones
Krinner S, Jung SY, Butola T, Wichmann C, Moser T

Front Syn Neurosci 2017 Oct 9th; doi: 10.3389/fnsyn.2017.00014
Piccolo promotes vesicle replenishment at a fast central auditory synapse
Butola T, Wichmann C, Moser T

EMBO reports 2017 Sep 11. e201643689; doi: 10.15252/embr.201643689
The BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing
Vogl C, Butola T, Haag N, Hausrat TJ, Leitner MG, Moutschen M, Lefèbvre PP, Speckmann C, Garrett L, Becker L, Fuchs H, Hrabe de Angelis M, Nietzsche S, Kessels MM, Oliver D, Kneussel M, Kilimann MW, Strenzke N

Sci Rep. 2017 Sep 22;7(1):12191. doi: 10.1038/s41598-017-12368-6.
A combination of NMDA and AMPA receptor antagonists retards granule cell dispersion and epileptogenesis in a model of acquired epilepsy
Schidlitzki A, Twele F, Klee R, Waltl I, Römermann T, Bröer S. Meller S, Gerhauser I, Rankovic V, Li D, Brandt D, Banksthal M, Töllner K, Löscher W

Front Cell Neurosci 2017 Jun 8;11:160. doi: 10.3389/fncel.2017.00160
Rab interacting molecules 2 and 3 directly interact with the pore-forming CaV1.3 Ca2+ channel subunit and promote its membrane expression
Picher MM, Oprişoreanu AM, Jung SY, Michel K, Schoch S, Moser T

Proc Natl Acad Sci U S A 2017 Feb 9. pii: 201617533
Ca2+-binding protein 2 inhibits Ca2+-channel inactivation in mouse inner hair cells
Picher MM, Gehrt A, Meese S, Ivanovic A, Predoehl F, Jung S, Schrauwen I, Dragonetti AG, Colombo R, Van Camp G, Strenzke N, Moser T

Neuroscience. 2017 Mar 6. 344:380-393. doi: 10.1016/j.neuroscience.2016.12.055
Conditional deletion of pejvakin in adult outer hair cells causes progressive hearing loss in mice
Harris SL., Kazmierczak M., Pangršič T., Shah P., Chuchvara N., Barrantes-Freer A., Moser T., Schwander M



2016

EMBO J. 2016 Dec 1. 35(23):2519-2535
Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants.
Strenzke N., Chakrabarti R., Al-Moyed H., Müller A., Hoch G., Pangrsic T., Yamanbaeva G., Lenz C., Pan KT., Auge E., Geiss-Friedlander R., Urlaub H., Brose N., Wichmann C., Reisinger E.

F1000Res. 2016 Aug 26;5. pii: F1000 Faculty Rev-2081. doi: 10.12688/f1000research.8924.1
New insights into cochlear sound encoding.
Moser T., Vogl C.

EMBO J 2016 Jul 25. doi 10.15252/embj.201593565| The EMBO Journal (2016) e201593565
Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing.
Vogl C., Panou I., Yamanbaeva G., Wichmann C., Mangosing S., Vilardi F., Indzhykulian A., Pangršič T., Santarelli R., Rodriguez-Ballesteros M., Weber T., Jung S., Cardenas E., Wu X., Wojcik S.M., Kwan K.Y., del Castillo I., Schwappach B., Strenzke N., Corey D.P., Lin S.Y., Moser T.

PNAS 2016 Jun 21. E4716–E4725, doi: 10.1073/pnas.1605737113
Hair cells use active zones with different voltage-dependence of Ca2+-influx to decompose sounds into complementary neural codes.
Ohn T.Z., Rutherford M.A., Jing Z., Jung S.Y., Duque-Afonso C.J., Hoch G., Picher M.M., Scharinger A., Strenzke N., Moser T.

Hum Mutat. 2016 Apr 11. doi: 10.1002/humu.22999.
DNA Diagnostics of Hereditary Hearing Loss: A Targeted Resequencing Approach Combined With a Mutation Classification System.
Sommen M., Schrauwen I., Vandeweyer G., Boeckx N., Corneveaux J.J., van den Ende J., Boudewyns A., De Leenheer E., Janssens S., Claes K., Verstreken M., Strenzke N., Predöhl F., Wuyts W., Mortier G., Bitner-Glindzicz M., Moser T., Coucke P., Huentelman M.J., Van Camp G.

EMBO J 2016 Apr 1. doi: 10.15252/embj.201694205. Comment.
Eyes without a ribbon.
Moser T.

Nat Rev Neurol. 2016 Feb 19. doi: 10.1038/nrneurol.2016.10. [Epub ahead of print]. Review.
Auditory neuropathy - neural and synaptic mechanisms.
Moser T., Starr A.



2015

The Primary Auditory Neurons of the Mammalian Cochlea, pp 117-156, 07 October 2015, Editors: Dabdoub, A., Fritzsch, B., Popper, A.N., Fay, R.R.
The Ribbon Synapse Between Type I Spiral Ganglion Neurons and Inner Hair Cells
Rutherford M.A., Moser T.

EMBO J. 2015 Oct 7. pii: e201591885. [Epub ahead of print].
Disruption of adaptor protein 2μ (AP-2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing.
Jung S, Maritzen T, Wichmann C, Jing Z, Neef A, Revelo NH, Al-Moyed H, Meese S, Wojcik SM, Panou I, Bulut H, Schu P, Ficner R, Reisinger E, Rizzoli SO, Neef J, Strenzke N, Haucke V, Moser T.

Hear Res. 2015 Dec;330(Pt B):178-90
Molecularly and structurally distinct synapses mediate reliable encoding and processing of auditory information.
Wichmann C.

Sci Transl Med. 2015 Jul 8;7(295):295fs28.
Gene therapy for deafness: How close are we?
Moser T.

Hear Res. 2015 Jun 26. pii: S0378-5955(15)00138-0.
Synaptic encoding and processing of auditory information in physiology and disease.
Moser T, Strenzke N.

Cell Tissue Res. 2015 Jul;361(1):95-114.
Relating structure and function of inner hair cell ribbon synapses.
Wichmann C, Moser T.

Proc Natl Acad Sci U S A. 2015 Jun 1. pii: 201417207.
Rab3-interacting molecules 2α and 2β promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zones.
Jung S, Oshima-Takago T, Chakrabarti R, Wong AB, Jing Z, Yamanbaeva G, Picher MM, Wojcik SM, Göttfert F, Predoehl F, Michel K, Hell SW, Schoch S, Strenzke N, Wichmann C, Moser T.

Proc Natl Acad Sci U S A. 2015 Feb 17. pii: 201416424. [Epub ahead of print]
EF-hand protein Ca2+ buffers regulate Ca2+ influx and exocytosis in sensory hair cells.
Pangršič T, Gabrielaitis M, Michanski S, Schwaller B, Wolf F, Strenzke N, Moser T.

J Cell Sci. 2015 Feb 15;128(4):638-44. doi: 10.1242/jcs.162099.[Epub ahead of print]
Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.
Vogl C, Cooper BH, Neef J, Wojcik SM, Reim K, Reisinger E, Brose N, Rhee JS, Moser T, Wichmann C.

Curr Opin Neurobiol. 2015 Jan 28;34C:29-36. doi:10.1016/j.conb.2015.01.004. Review.
Optogenetic stimulation of the auditory pathway for research and future prosthetics.
Moser T.

Hear Res. 2015 Jan 16. pii: S0378-5955(15)00008-8. doi:10.1016/j.heares.2015.01.005. Review.
Considering optogenetic stimulation for cochlear implants.
Jeschke M, Moser T.



2014

J Vis Exp. 2014 Oct 8;(92):e52069. doi: 10.3791/52069.
Optogenetic stimulation of the auditory nerve.
Hernandez VH, Gehrt A, Jing Z, Hoch G, Jeschke M, Strenzke N, Moser T.

Neuron. 2014 Sep 3, pii: S0896-6273(14)00678-3. doi: 10.1016/j.neuron.2014.08.003. [Epub ahead of print]
Uniquantal Release through a Dynamic Fusion Pore Is a Candidate Mechanism of Hair Cell Exocytosis.
Chapochnikov NM, Takago H, Huang CH, Pangršič T, Khimich D, Neef J, Auge E, Göttfert F, Hell SW, Wichmann C, Wolf F, Moser T.

J Cell Biol. 2014 May 26;205(4):591-606. doi:10.1083/jcb.201402066.
A new probe for super-resolution imaging of membranes elucidates trafficking pathways.
Revelo NH, Kamin D, Truckenbrodt S, Wong AB, Reuter-Jessen K, Reisinger E, Moser T, Rizzoli SO.

J Neurosci. 2014 May 14;34(20):6843-8. doi: 10.1523/JNEUROSCI.4990-13.2014
ATP hydrolysis is critically required for function of CaV1.3 channels in cochlear inner hair cells via fueling Ca2+ clearance.
Weiler S, Krinner S, Wong AB, Moser T, Pangršič T.

EMBO J. 2014 Mar 3;33(5):512-27. doi:10.1002/embj.201385887.
Bassoon-disruption slows vesicle replenishment and induces homeostatic plasticity at a CNS synapse.
Mendoza Schulz A, Jing Z, Sánchez Caro JM, Wetzel F, Dresbach T, Strenzke N, Wichmann C, Moser T.

J Clin Invest. 2014 Mar 3;124(3):1114-29. doi:10.1172/JCI69050.
Optogenetic stimulation of the auditory pathway.
Hernandez VH, Gehrt A, Reuter K, Jing Z, Jeschke M, Mendoza Schulz A, Hoch G, Bartels M, Vogt G, Garnham CW, Yawo H, Fukazawa Y, Augustine GJ, Bamberg E, Kügler S, Salditt T, de Hoz L, Strenzke N, Moser T.

EMBO J. 2014 Feb 3;33(3):247-64. doi: 10.1002/embj.201387110.
Developmental refinement of hair cell synapses tightens the coupling of Ca2+ influx to exocytosis.
Wong AB, Rutherford MA, Gabrielaitis M, Pangrsic T, Göttfert F, Frank T, Michanski S, Hell S, Wolf F, Wichmann C, Moser T.

J Neurosci. 2014 Jan 15;34(3):705-16. doi: 10.1523/JNEUROSCI.3313-13.2014.
Modes and regulation of endocytic membrane retrieval in mouse auditory hair cells.
Neef J, Jung S, Wong AB, Reuter K, Pangrsic T, Chakrabarti R, Kügler S, Lenz C, Nouvian R, Boumil RM, Frankel WN, Wichmann C, Moser T.

Otol Neurotol. 2013 Aug;34(6):995-1004. doi:10.1097/MAO.0b013e3182814d4a. Review.
Review of hair cell synapse defects in sensorineural hearing impairment.
Moser T, Predoehl F, Starr A.



2013

J Physiol. 2013 Jul 1;591(Pt 13):3253-69. doi:10.1113/jphysiol.2013.254367.
Harmonin enhances voltage-dependent facilitation of CaV1.3 channels and synchronous exocytosis in mouse inner hair cells.
Gregory FD, Pangrsic T, Calin-Jageman IE, Moser T, Lee A.

J Neurosci. 2013 Jun 26;33(26):10661-6. doi: 10.1523/JNEUROSCI.1215-13.2013.
Concurrent maturation of inner hair cell synaptic Ca2+ influx and auditory nerve spontaneous activity around hearing onset in mice.
Wong AB, Jing Z, Rutherford MA, Frank T, Strenzke N, Moser T.

Glia. 2013 Apr;61(4):567-86. doi: 10.1002/glia.22456.
A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system.
Werner HB, Krämer-Albers EM, Strenzke N, Saher G, Tenzer S, Ohno-Iwashita Y, De Monasterio-Schrader P, Möbius W, Moser T, Griffiths IR, Nave KA.

J Neurosci. 2013 Mar 6;33(10):4456-67. doi:10.1523/JNEUROSCI.3491-12.2013.
Disruption of the presynaptic cytomatrix protein bassoon degrades ribbon anchorage, multiquantal release, and sound encoding at the hair cell afferent synapse.
Jing Z, Rutherford MA, Takago H, Frank T, Fejtova A, Khimich D, Moser T, Strenzke N.

Nat Commun. 2013;4:1438. doi: 10.1038/ncomms2445.
Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells.
Defourny J, Poirrier AL, Lallemend F, Mateo Sánchez S, Neef J, Vanderhaeghen P, Soriano E, Peuckert C, Kullander K, Fritzsch B, Nguyen L, Moonen G, Moser T, Malgrange B.



2012

Am J Hum Genet. 2012 Nov 2;91(5):919-27. doi: 10.1016/j.ajhg.2012.09.002.
A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss.
von Ameln S, Wang G, Boulouiz R, Rutherford MA, Smith GM, Li Y, Pogoda HM, Nürnberg G, Stiller B, Volk AE, Borck G, Hong JS, Goodyear RJ, Abidi O, Nürnberg P, Hofmann K, Richardson GP, Hammerschmidt M, Moser T, Wollnik B, Koehler CM, Teitell MA, Barakat A, Kubisch C.

Trends Neurosci. 2012 Nov;35(11):671-80. doi:10.1016/j.tins.2012.08.002. Review.
Otoferlin: a multi-C2 domain protein essential for hearing.
Pangršič T, Reisinger E, Moser T.

Am J Hum Genet. 2012 Oct 5;91(4):636-45. doi: 10.1016/j.ajhg.2012.08.018.
A mutation in CABP2, expressed in cochlear hair cells, causes autosomal-recessive hearing impairment.
Schrauwen I, Helfmann S, Inagaki A, Predoehl F, Tabatabaiefar MA, Picher MM, Sommen M, Seco CZ, Oostrik J, Kremer H, Dheedene A, Claes C, Fransen E, Chaleshtori MH, Coucke P, Lee A, Moser T, Van Camp G.

J Neurosci. 2012 Aug 29;32(35):12192-203.
Deletion of the presynaptic scaffold CAST reduces active zone size in rod photoreceptors and impairs visualprocessing.
tom Dieck S, Specht D, Strenzke N, Hida Y, Krishnamoorthy V, Schmidt KF, Inoue E, Ishizaki H, Tanaka-Okamoto M, Miyoshi J, Hagiwara A, Brandstätter JH, Löwel S, Gollisch T, Ohtsuka T, Moser T.

HNO. 2012 Aug;60(8):707-14. doi: 10.1007/s00106-011-2457-y. German.
Super-resolution optical microscopy of the organ of Corti. Investigations on the fine structure of the inner hair cell afferent synapse by the 4Pi and STED techniques.
Meyer AC, Khimich D, Egner A, Moser T.

J Neurosci. 2012 Jul 11;32(28):9485-98. doi:10.1523/JNEUROSCI.0311-12.2012.
The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene.
Geng R, Melki S, Chen DH, Tian G, Furness DN, Oshima-Takago T, Neef J, Moser T, Askew C, Horwitz G, Holt JR, Imanishi Y, Alagramam KN.

J Neurosci. 2012 Apr 4;32(14):4773-89. doi: 10.1523/JNEUROSCI.4511-11.2012.
Spike encoding of neurotransmitterrelease timing by spiral ganglion neurons of the cochlea.
Rutherford MA, Chapochnikov NM, Moser T.

Physiology (Bethesda). 2012 Apr;27(2):100-12. doi: 10.1152/physiol.00036.2011. Review.
Neural circuit development in the mammalian cochlea.
Bulankina AV, Moser T.



2011

Eur J Cell Biol.2011 Oct;90(10):817-24. doi: 10.1016/j.ejcb.2011.05.001.
Connexin32 can restore hearing in connexin26 deficient mice.
Degen J, Schütz M, Dicke N, Strenzke N, Jokwitz M, Moser T, Willecke K.

Nat Neurosci. 2011 Aug 7;14(9):1109-11. doi: 10.1038/nn.2895.
Harmonin inhibits presynaptic CaV1.3 Ca2+ channels in mouse inner hair cells.
Gregory FD, Bryan KE, Pangršič T, Calin-Jageman IE, Moser T, Lee A.

EMBO J. 2011 Jun 24;30(14):2793-804. doi:10.1038/emboj.2011.202.
A synthetic prestin reveals protein domains and molecular operation of outer hair cell piezoelectricity.
Schaechinger TJ, Gorbunov D, Halaszovich CR, Moser T, Kügler S, Fakler B, Oliver D.

Nat Neurosci. 2011 Apr;14(4):411-3. doi: 10.1038/nn.2774.
Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins.
Nouvian R, Neef J, Bulankina AV, Reisinger E, Pangršič T, Frank T, Sikorra S, Brose N, Binz T, Moser T.

J Neurosci. 2011 Mar 30;31(13):4886-95. doi:10.1523/JNEUROSCI.5122-10.2011.
Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis.
Reisinger E, Bresee C, Neef J, Nair R, Reuter K, Bulankina A, Nouvian R, Koch M, Bückers J, Kastrup L, Roux I, Petit C, Hell SW, Brose N, Rhee JS, Kügler S, Brigande JV, Moser T.

J Mol Biol. 2011 Feb 25;406(3):479-90. doi:10.1016/j.jmb.2010.12.031.
The crystal structure of the C₂A domain of otoferlin reveals an unconventional top loop region.
Helfmann S, Neumann P, Tittmann K, Moser T, Ficner R, Reisinger E.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3053-8. doi:10.1073/pnas.1006946108. Epub 2011 Jan 31.
Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.
Hoon M, Soykan T, Falkenburger B, Hammer M, Patrizi A, Schmidt KF, Sassoè-Pognetto M, Löwel S, Moser T, Taschenberger H, Brose N, Varoqueaux F.

Hum Mol Genet. 2011 Jan 1;20(1):28-39.doi: 10.1093/hmg/ddq429.
The connexin26 S17F mouse mutant represents a model for the human hereditary keratitis-ichthyosis-deafness syndrome.
Schütz M, Auth T, Gehrt A, Bosen F, Körber I, Strenzke N, Moser T, Willecke K.



2006 - 2010

Neuron. 2010 Nov 18;68(4):724-38. doi:10.1016/j.neuron.2010.10.027.
Bassoon and the synaptic ribbon organize Ca²+ channels and vesicles to add release sites and promote refilling.
Frank T, Rutherford MA, Strenzke N, Neef A, Pangršič T, Khimich D, Fejtova A, Gundelfinger ED, Liberman MC, Harke B, Bryan KE, Lee A, Egner A, Riedel D, Moser T.

Curr Opin Otolaryngol Head Neck Surg. 2010 Oct;18(5):441-6. doi:10.1097/MOO.0b013e32833e0586. Review.
Structure and function of cochlear afferent innervation.
Meyer AC, Moser T.

PLoS Genet. 2010 Aug 5;6(8). pii: e1001046. doi:10.1371/journal.pgen.1001046.
A missense mutation in a highly conserved alternate exon of dynamin-1 causes epilepsy in fitful mice.
Boumil RM, Letts VA, Roberts MC, Lenz C, Mahaffey CL, Zhang ZW, Moser T, Frankel WN.

Nat Neurosci. 2010 Jul;13(7):869-76. doi: 10.1038/nn.2578.
Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells.
Pangrsic T, Lasarow L, Reuter K, Takago H, Schwander M, Riedel D, Frank T, Tarantino LM, Bailey JS, Strenzke N, Brose N, Müller U, Reisinger E, Moser T.

J Neurosci. 2010 Jun 2;30(22):7587-97. doi:10.1523/JNEUROSCI.0389-10.2010.
Onset coding is degraded in auditory nerve fibers from mutant mice lacking synaptic ribbons.
Buran BN, Strenzke N, Neef A, Gundelfinger ED, Moser T, Liberman MC.

J Neurosci. 2009 Oct 14;29(41):12802-6. doi: 10.1523/JNEUROSCI.3346-09.2009. Review.
Functional properties of synaptic transmission in primary sense organs.
Singer JH, Glowatzki E, Moser T, Strowbridge BW, Bhandawat V, Sampath AP.

J Neurosci. 2009 Aug 26;29(34):10730-40. doi: 10.1523/JNEUROSCI.1577-09.2009.
The Ca2+ channel subunit beta2 regulates Ca2+ channel abundance and function in inner hair cells and is required for hearing.
Neef J, Gehrt A, Bulankina AV, Meyer AC, Riedel D, Gregg RG, Strenzke N, Moser T.

J Neurosci. 2009 Jun 24;29(25):8039-50. doi:10.1523/JNEUROSCI.0534-09.2009.
Neuroligin 2 controls the maturation of GABAergic synapses and information processing in the retina.
Hoon M, Bauer G, Fritschy JM, Moser T, Falkenburger BH, Varoqueaux F.

J Neurosci. 2009 Jun 24;29(25):7991-8004. doi: 10.1523/JNEUROSCI.0632-09.2009.
Complexin-I is required for high-fidelity transmission at the endbulb of Held auditory synapse.
Strenzke N, Chanda S, Kopp-Scheinpflug C, Khimich D, Reim K, Bulankina AV, Neef A, Wolf F, Brose N, Xu-Friedman MA, Moser T.

BMC Neurosci. 2009 May 29;10:54. doi: 10.1186/1471-2202-10-54.
Does a single session of theta-burst transcranial magnetic stimulation of inferior temporal cortex affect tinnitus perception?
Poreisz C, Paulus W, Moser T, Lang N.

Nat Neurosci. 2009 Apr;12(4):444-53. doi:10.1038/nn.2293.
Tuning of synapse number, structure and function in the cochlea.
Meyer AC, Frank T, Khimich D, Hoch G, Riedel D, Chapochnikov NM, Yarin YM, Harke B, Hell SW, Egner A, Moser T.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4483-8. doi: 10.1073/pnas.0813213106.
Mechanisms contributing to synaptic Ca2+ signals and their heterogeneity in hair cells.
Frank T, Khimich D, Neef A, Moser T.

Am J Hum Genet. 2008 Aug;83(2):278-92. doi:10.1016/j.ajhg.2008.07.008.
Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice.
Ruel J, Emery S, Nouvian R, Bersot T, Amilhon B, Van Rybroek JM, Rebillard G, Lenoir M, Eybalin M, Delprat B, Sivakumaran TA, Giros B, El Mestikawy S, Moser T, Smith RJ, Lesperance MM, Puel JL.

J Physiol. 2007 Dec 15;585(Pt 3):791-803.
Ca2+-binding proteins tune Ca2+-feedback to CaV1.3 channels in mouse auditory hair cells.
Cui G, Meyer AC, Calin-Jageman I, Neef J, Haeseleer F, Moser T, Lee A.

J Neurosci. 2007 Nov 21;27(47):12933-44.
Probing the mechanism of exocytosis at the hair cell ribbon synapse.
Neef A, Khimich D, Pirih P, Riedel D, Wolf F, Moser T.

Neuroscience. 2007 Nov 9;149(3):673-84.
Detection and differentiation of sensorineural hearing loss in mice using auditory steady-state responses and transient auditory brainstem responses.
Pauli-Magnus D, Hoch G, Strenzke N, Anderson S, Jentsch TJ, Moser T.

Pflugers Arch. 2007 May;454(2):335-44.
Measurements of membrane patch capacitance using a software-based lock-in system.
Neef A, Heinemann C, Moser T.

J Neurosci. 2007 Mar 21;27(12):3163-73.
Maturation of ribbon synapses in hair cells is driven by thyroid hormone.
Sendin G, Bulankina AV, Riedel D, Moser T.

Cell Tissue Res. 2006 Nov;326(2):347-59. Review.
Hair cell ribbon synapses.
Moser T, Brandt A, Lysakowski A.

HNO. 2006 Nov;54(11):833-9. Review. German.
Diagnosis and therapy of auditory synaptopathy/neuropathy.
Moser T, Strenzke N, Meyer A, Lesinski-Schiedat A, Lenarz T, Beutner D, Foerst A, Lang-Roth R, von Wedel H, Walger M, Gross M, Keilmann A, Limberger A, Steffens T, Strutz J.

Cell. 2006 Oct 20;127(2):277-89.
Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse.
Roux I, Safieddine S, Nouvian R, Grati M, Simmler MC, Bahloul A, Perfettini I, Le Gall M, Rostaing P, Hamard G, Triller A, Avan P, Moser T, Petit C.

J Physiol. 2006 Oct 1;576(Pt 1):55-62. Epub 2006 Aug 10. Review.
Mechanisms underlying the temporal precision of sound coding at the inner hair cell ribbon synapse.
Moser T, Neef A, Khimich D

Laryngorhinootologie. 2006 Oct;85(10):709-11. German.
Hearing loss -- can heat shock protein 70 be cited as prognostic marker?
Krome S, Moser T, Lenarz T.

Ca2+ channels. Neuroscience. 2006 Sep 15;141(4):1849-60.
Synaptic organization in cochlear inner hair cells deficient for the CaV1.3 (alpha1D) subunit of L-type.
Nemzou N RM, Bulankina AV, Khimich D, Giese A, Moser T.

Glia. 2006 Apr 15;53(6):601-11.
Expression pattern and functional characterization of connexin29 in transgenic mice.
Eiberger J, Kibschull M, Strenzke N, Schober A, Büssow H, Wessig C, Djahed S, Reucher H, Koch DA, Lautermann J, Moser T, Winterhager E, Willecke K.

Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2926-31.
CSPalpha-deficiency causes massive and rapid photoreceptor degeneration.
Schmitz F, Tabares L, Khimich D, Strenzke N, de la Villa-Polo P, Castellano-Muñoz M, Bulankina A, Moser T, Fernández-Chacón R, Südhof TC.

EMBO J. 2006 Feb8;25(3):642-52.
Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness.
Kharkovets T, Dedek K, Maier H, Schweizer M, Khimich D, Nouvian R, Vardanyan V, Leuwer R, Moser T, Jentsch TJ.

J Membr Biol. 2006 Feb-Mar;209(2-3):153-65. Review.
Structure and function of the hair cell ribbon synapse.
Nouvian R, Beutner D, Parsons TD, Moser T.

Neuroscience. 2006;138(2):433-46.
alpha-Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction.
Sons MS, Busche N, Strenzke N, Moser T, Ernsberger U, Mooren FC, Zhang W, Ahmad M, Steffens H, Schomburg ED, Plomp JJ, Missler M.



2001 - 2005

J Neurosci. 2005 Dec 14;25(50):11577-85.
Few CaV1.3 channels regulate the exocytosis of a synaptic vesicle at the hair cell ribbon synapse.
Brandt A, Khimich D, Moser T.

Nature. 2005 Apr 14;434(7035):889-94.
Hair cell synaptic ribbons are essential for synchronous auditory signalling.
Khimich D, Nouvian R, Pujol R, Tom Dieck S, Egner A, Gundelfinger ED, Moser T.

J Neurosci. 2003 Nov 26;23(34):10832-40.
CaV1.3 channels are essential for development and presynaptic activity of cochlear inner hair cells.
Brandt A, Striessnig J, Moser T.

Curr Opin Neurobiol. 2003 Aug;13(4):452-8. Review.
The afferent synapse of cochlear hair cells.
Fuchs PA, Glowatzki E, Moser T.

Nat Neurosci. 2003 Aug;6(8):846-53.
Calcium regulates exocytosis at the level of single vesicles.
Becherer U, Moser T, Stühmer W, Oheim M.

HNO. 2002 May;50(5):415-7. German.
Synaptic function in the auditory pathway and genetics of hearing loss.
Ohlrogge M, Moser T.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11680-5.
Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I.
Voets T, Moser T, Lund PE, Chow RH, Geppert M, Südhof TC, Neher E.

Neuron. 2001 Aug 30;31(4):581-91.
Munc18-1 promotes large dense-core vesicle docking.
Voets T, Toonen RF, Brian EC, de Wit H, Moser T, Rettig J, Südhof TC, Neher E, Verhage M.

J Neurosci. 2001 Jul 1;21(13):4593-9.
The presynaptic function of mouse cochlear inner hair cells during development of hearing.
Beutner D, Moser T.

Neuron. 2001 Mar;29(3):681-90.
Calcium dependence of exocytosis and endocytosis at the cochlear inner hair cell afferent synapse.
Beutner D, Voets T, Neher E, Moser T.



1995 - 2000

J Neurosci. 2000 Nov 15;20(22):8377-83.
The readily releasable pool of vesicles in chromaffin cells is replenished in a temperature-dependent manner and transiently overfills at 37 degrees C.
Dinkelacker V, Voets T, Neher E, Moser T.

J Neurosci. 2000 Nov 15;20(22):8323-30.
R-Type Ca2+ channels are coupled to the rapid component of secretion in mouse adrenal slice chromaffin cells.
Albillos A, Neher E, Moser T.

Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):883-8.
Kinetics of exocytosis and endocytosis at the cochlear inner hair cell afferent synapse of the mouse.
Moser T, Beutner D.

Neuron. 1999 Jul;23(3):607-15.
Mechanisms underlying phasic and sustained secretion in chromaffin cells from mouse adrenal slices.
Voets T, Neher E, Moser T.

Neuron. 1998 Jun;20(6):1243-53.
Cytosolic Ca2+ acts by two separate pathways to modulate the supply of release-competent vesicles in chromaffin cells.
Smith C, Moser T, Xu T, Neher E.

J Physiol. 1998 Jan 1;506 ( Pt 1):195-205.
Low-conductance intercellular coupling between mouse chromaffin cells in situ.
Moser T.

Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6735-40.
Estimation of mean exocytic vesicle capacitance in mouse adrenal chromaffin cells.
Moser T, Neher E.

J Neurosci. 1997 Apr 1;17(7):2314-23.
Rapid exocytosis in single chromaffin cells recorded from mouse adrenal slices.
Moser T, Neher E.

Pflugers Arch. 1995 Dec;431(2):196-203.
Swelling-induced catecholamine secretion recorded from single chromaffin cells.
Moser T, Chow RH, Neher E.