News - Publications

2017

Front Cell Neurosci 2017; in press
Rab interacting molecules 2 and 3 directly interact with the pore-forming CaV1.3 Ca2+ channel subunit and promote its membrane expression
Picher MM, Oprişoreanu AM, Jung SY, Michel K, Schoch S, Moser T

Proc Natl Acad Sci U S A 2017 Feb 9. pii: 201617533
Ca2+-binding protein 2 inhibits Ca2+-channel inactivation in mouse inner hair cells
Picher MM, Gehrt A, Meese S, Ivanovic A, Predoehl F, Jung S, Schrauwen I, Dragonetti AG, Colombo R, Van Camp G, Strenzke N, Moser T

Neuroscience. 2017 Mar 6. 344:380-393. doi: 10.1016/j.neuroscience.2016.12.055
Conditional deletion of pejvakin in adult outer hair cells causes progressive hearing loss in mice
Harris SL., Kazmierczak M., Pangršič T., Shah P., Chuchvara N., Barrantes-Freer A., Moser T., Schwander M

2016

EMBO J. 2016 Dec 1;35(23):2519-2535
Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants.
Strenzke N., Chakrabarti R., Al-Moyed H., Müller A., Hoch G., Pangrsic T., Yamanbaeva G., Lenz C., Pan KT., Auge E., Geiss-Friedlander R., Urlaub H., Brose N., Wichmann C., Reisinger E.

F1000Res. 2016 Aug 26;5. pii: F1000 Faculty Rev-2081. doi: 10.12688/f1000research.8924.1
New insights into cochlear sound encoding.
Moser T., Vogl C.

EMBO J 2016 Jul 25 doi 10.15252/embj.201593565| The EMBO Journal (2016) e201593565
Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing.
Vogl C., Panou I., Yamanbaeva G., Wichmann C., Mangosing S., Vilardi F., Indzhykulian A., Pangršič T., Santarelli R., Rodriguez-Ballesteros M., Weber T., Jung S., Cardenas E., Wu X., Wojcik S.M., Kwan K.Y., del Castillo I., Schwappach B., Strenzke N., Corey D.P., Lin S.Y., Moser T.

PNAS 2016 Jun 21. E4716–E4725, doi: 10.1073/pnas.1605737113
Hair cells use active zones with different voltage-dependence of Ca2+-influx to decompose sounds into complementary neural codes.
Ohn T.Z., Rutherford M.A., Jing Z., Jung S.Y., Duque-Afonso C.J., Hoch G., Picher M.M., Scharinger A., Strenzke N., Moser T.

Hum Mutat. 2016 Apr 11. doi: 10.1002/humu.22999.
DNA Diagnostics of Hereditary Hearing Loss: A Targeted Resequencing Approach Combined With a Mutation Classification System.
Sommen M., Schrauwen I., Vandeweyer G., Boeckx N., Corneveaux J.J., van den Ende J., Boudewyns A., De Leenheer E., Janssens S., Claes K., Verstreken M., Strenzke N., Predöhl F., Wuyts W., Mortier G., Bitner-Glindzicz M., Moser T., Coucke P., Huentelman M.J., Van Camp G.

EMBO J 2016 Apr 1. doi: 10.15252/embj.201694205. Comment.
Eyes without a ribbon.
Moser T.

Nat Rev Neurol. 2016 Feb 19. doi: 10.1038/nrneurol.2016.10. [Epub ahead of print]. Review.
Auditory neuropathy - neural and synaptic mechanisms.
Moser T., Starr A.



2015

The Primary Auditory Neurons of the Mammalian Cochlea, pp 117-156, 07 October 2015, Editors: Dabdoub, A., Fritzsch, B., Popper, A.N., Fay, R.R.
The Ribbon Synapse Between Type I Spiral Ganglion Neurons and Inner Hair Cells
Rutherford M.A., Moser T.

EMBO J. 2015 Oct 7. pii: e201591885. [Epub ahead of print].
Disruption of adaptor protein 2μ (AP-2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing.
Jung S, Maritzen T, Wichmann C, Jing Z, Neef A, Revelo NH, Al-Moyed H, Meese S, Wojcik SM, Panou I, Bulut H, Schu P, Ficner R, Reisinger E, Rizzoli SO, Neef J, Strenzke N, Haucke V, Moser T.

Hear Res. 2015 Dec;330(Pt B):178-90
Molecularly and structurally distinct synapses mediate reliable encoding and processing of auditory information.
Wichmann C.

Sci Transl Med. 2015 Jul 8;7(295):295fs28.
Gene therapy for deafness: How close are we? publications publications
Moser T.

Hear Res. 2015 Jun 26. pii: S0378-5955(15)00138-0.
Synaptic encoding and processing of auditory information in physiology and disease.
Moser T, Strenzke N.

Cell Tissue Res. 2015 Jul;361(1):95-114.
Relating structure and function of inner hair cell ribbon synapses.
Wichmann C, Moser T.

Proc Natl Acad Sci U S A. 2015 Jun 1. pii: 201417207.
Rab3-interacting molecules 2α and 2β promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zones.
Jung S, Oshima-Takago T, Chakrabarti R, Wong AB, Jing Z, Yamanbaeva G, Picher MM, Wojcik SM, Göttfert F, Predoehl F, Michel K, Hell SW, Schoch S, Strenzke N, Wichmann C, Moser T.

Proc Natl Acad Sci U S A. 2015 Feb 17. pii: 201416424. [Epub ahead of print]
EF-hand protein Ca2+ buffers regulate Ca2+ influx and exocytosis in sensory hair cells.
Pangršič T, Gabrielaitis M, Michanski S, Schwaller B, Wolf F, Strenzke N, Moser T.

J Cell Sci. 2015 Feb 15;128(4):638-44. doi: 10.1242/jcs.162099.[Epub ahead of print]
Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.
Vogl C, Cooper BH, Neef J, Wojcik SM, Reim K, Reisinger E, Brose N, Rhee JS, Moser T, Wichmann C.

Curr Opin Neurobiol. 2015 Jan 28;34C:29-36. doi:10.1016/j.conb.2015.01.004. Review.
Optogenetic stimulation of the auditory pathway for research and future prosthetics.
Moser T.

Hear Res. 2015 Jan 16. pii: S0378-5955(15)00008-8. doi:10.1016/j.heares.2015.01.005. Review.
Considering optogenetic stimulation for cochlear implants.
Jeschke M, Moser T.



2014

J Vis Exp. 2014 Oct 8;(92):e52069. doi: 10.3791/52069.
Optogenetic stimulation of the auditory nerve.
Hernandez VH, Gehrt A, Jing Z, Hoch G, Jeschke M, Strenzke N, Moser T.

Neuron. 2014 Sep 3, pii: S0896-6273(14)00678-3. doi: 10.1016/j.neuron.2014.08.003. [Epub ahead of print]
Uniquantal Release through a Dynamic Fusion Pore Is a Candidate Mechanism of Hair Cell Exocytosis.
Chapochnikov NM, Takago H, Huang CH, Pangršič T, Khimich D, Neef J, Auge E, Göttfert F, Hell SW, Wichmann C, Wolf F, Moser T.

J Cell Biol. 2014 May 26;205(4):591-606. doi:10.1083/jcb.201402066.
A new probe for super-resolution imaging of membranes elucidates trafficking pathways.
Revelo NH, Kamin D, Truckenbrodt S, Wong AB, Reuter-Jessen K, Reisinger E, Moser T, Rizzoli SO.

J Neurosci. 2014 May 14;34(20):6843-8. doi: 10.1523/JNEUROSCI.4990-13.2014
ATP hydrolysis is critically required for function of CaV1.3 channels in cochlear inner hair cells via fueling Ca2+ clearance.
Weiler S, Krinner S, Wong AB, Moser T, Pangršič T.

EMBO J. 2014 Mar 3;33(5):512-27. doi:10.1002/embj.201385887.
Bassoon-disruption slows vesicle replenishment and induces homeostatic plasticity at a CNS synapse.
Mendoza Schulz A, Jing Z, Sánchez Caro JM, Wetzel F, Dresbach T, Strenzke N, Wichmann C, Moser T.

J Clin Invest. 2014 Mar 3;124(3):1114-29. doi:10.1172/JCI69050.
Optogenetic stimulation of the auditory pathway.
Hernandez VH, Gehrt A, Reuter K, Jing Z, Jeschke M, Mendoza Schulz A, Hoch G, Bartels M, Vogt G, Garnham CW, Yawo H, Fukazawa Y, Augustine GJ, Bamberg E, Kügler S, Salditt T, de Hoz L, Strenzke N, Moser T.

EMBO J. 2014 Feb 3;33(3):247-64. doi: 10.1002/embj.201387110.
Developmental refinement of hair cell synapses tightens the coupling of Ca2+ influx to exocytosis.
Wong AB, Rutherford MA, Gabrielaitis M, Pangrsic T, Göttfert F, Frank T, Michanski S, Hell S, Wolf F, Wichmann C, Moser T.

J Neurosci. 2014 Jan 15;34(3):705-16. doi: 10.1523/JNEUROSCI.3313-13.2014.
Modes and regulation of endocytic membrane retrieval in mouse auditory hair cells.
Neef J, Jung S, Wong AB, Reuter K, Pangrsic T, Chakrabarti R, Kügler S, Lenz C, Nouvian R, Boumil RM, Frankel WN, Wichmann C, Moser T.

Otol Neurotol. 2013 Aug;34(6):995-1004. doi:10.1097/MAO.0b013e3182814d4a. Review.
Review of hair cell synapse defects in sensorineural hearing impairment.
Moser T, Predoehl F, Starr A.



2013

J Physiol. 2013 Jul 1;591(Pt 13):3253-69. doi:10.1113/jphysiol.2013.254367.
Harmonin enhances voltage-dependent facilitation of CaV1.3 channels and synchronous exocytosis in mouse inner hair cells.
Gregory FD, Pangrsic T, Calin-Jageman IE, Moser T, Lee A.

J Neurosci. 2013 Jun 26;33(26):10661-6. doi: 10.1523/JNEUROSCI.1215-13.2013.
Concurrent maturation of inner hair cell synaptic Ca2+ influx and auditory nerve spontaneous activity around hearing onset in mice.
Wong AB, Jing Z, Rutherford MA, Frank T, Strenzke N, Moser T.

Glia. 2013 Apr;61(4):567-86. doi: 10.1002/glia.22456.
A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system.
Werner HB, Krämer-Albers EM, Strenzke N, Saher G, Tenzer S, Ohno-Iwashita Y, De Monasterio-Schrader P, Möbius W, Moser T, Griffiths IR, Nave KA.

J Neurosci. 2013 Mar 6;33(10):4456-67. doi:10.1523/JNEUROSCI.3491-12.2013.
Disruption of the presynaptic cytomatrix protein bassoon degrades ribbon anchorage, multiquantal release, and sound encoding at the hair cell afferent synapse.
Jing Z, Rutherford MA, Takago H, Frank T, Fejtova A, Khimich D, Moser T, Strenzke N.

Nat Commun. 2013;4:1438. doi: 10.1038/ncomms2445.
Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells.
Defourny J, Poirrier AL, Lallemend F, Mateo Sánchez S, Neef J, Vanderhaeghen P, Soriano E, Peuckert C, Kullander K, Fritzsch B, Nguyen L, Moonen G, Moser T, Malgrange B.



2012

Am J Hum Genet. 2012 Nov 2;91(5):919-27. doi: 10.1016/j.ajhg.2012.09.002.
A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss.
von Ameln S, Wang G, Boulouiz R, Rutherford MA, Smith GM, Li Y, Pogoda HM, Nürnberg G, Stiller B, Volk AE, Borck G, Hong JS, Goodyear RJ, Abidi O, Nürnberg P, Hofmann K, Richardson GP, Hammerschmidt M, Moser T, Wollnik B, Koehler CM, Teitell MA, Barakat A, Kubisch C.

Trends Neurosci. 2012 Nov;35(11):671-80. doi:10.1016/j.tins.2012.08.002. Review.
Otoferlin: a multi-C2 domain protein essential for hearing.
Pangršič T, Reisinger E, Moser T.

Am J Hum Genet. 2012 Oct 5;91(4):636-45. doi: 10.1016/j.ajhg.2012.08.018.
A mutation in CABP2, expressed in cochlear hair cells, causes autosomal-recessive hearing impairment.
Schrauwen I, Helfmann S, Inagaki A, Predoehl F, Tabatabaiefar MA, Picher MM, Sommen M, Seco CZ, Oostrik J, Kremer H, Dheedene A, Claes C, Fransen E, Chaleshtori MH, Coucke P, Lee A, Moser T, Van Camp G.

J Neurosci. 2012 Aug 29;32(35):12192-203.
Deletion of the presynaptic scaffold CAST reduces active zone size in rod photoreceptors and impairs visualprocessing.
tom Dieck S, Specht D, Strenzke N, Hida Y, Krishnamoorthy V, Schmidt KF, Inoue E, Ishizaki H, Tanaka-Okamoto M, Miyoshi J, Hagiwara A, Brandstätter JH, Löwel S, Gollisch T, Ohtsuka T, Moser T.

HNO. 2012 Aug;60(8):707-14. doi: 10.1007/s00106-011-2457-y. German.
Super-resolution optical microscopy of the organ of Corti. Investigations on the fine structure of the inner hair cell afferent synapse by the 4Pi and STED techniques.
Meyer AC, Khimich D, Egner A, Moser T.

J Neurosci. 2012 Jul 11;32(28):9485-98. doi:10.1523/JNEUROSCI.0311-12.2012.
The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene.
Geng R, Melki S, Chen DH, Tian G, Furness DN, Oshima-Takago T, Neef J, Moser T, Askew C, Horwitz G, Holt JR, Imanishi Y, Alagramam KN.

J Neurosci. 2012 Apr 4;32(14):4773-89. doi: 10.1523/JNEUROSCI.4511-11.2012.
Spike encoding of neurotransmitterrelease timing by spiral ganglion neurons of the cochlea.
Rutherford MA, Chapochnikov NM, Moser T.

Physiology (Bethesda). 2012 Apr;27(2):100-12. doi: 10.1152/physiol.00036.2011. Review.
Neural circuit development in the mammalian cochlea.
Bulankina AV, Moser T.



2011

Eur J Cell Biol.2011 Oct;90(10):817-24. doi: 10.1016/j.ejcb.2011.05.001.
Connexin32 can restore hearing in connexin26 deficient mice.
Degen J, Schütz M, Dicke N, Strenzke N, Jokwitz M, Moser T, Willecke K.

Nat Neurosci. 2011 Aug 7;14(9):1109-11. doi: 10.1038/nn.2895.
Harmonin inhibits presynaptic CaV1.3 Ca2+ channels in mouse inner hair cells.
Gregory FD, Bryan KE, Pangršič T, Calin-Jageman IE, Moser T, Lee A.

EMBO J. 2011 Jun 24;30(14):2793-804. doi:10.1038/emboj.2011.202.
A synthetic prestin reveals protein domains and molecular operation of outer hair cell piezoelectricity.
Schaechinger TJ, Gorbunov D, Halaszovich CR, Moser T, Kügler S, Fakler B, Oliver D.

Nat Neurosci. 2011 Apr;14(4):411-3. doi: 10.1038/nn.2774.
Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins.
Nouvian R, Neef J, Bulankina AV, Reisinger E, Pangršič T, Frank T, Sikorra S, Brose N, Binz T, Moser T.

J Neurosci. 2011 Mar 30;31(13):4886-95. doi:10.1523/JNEUROSCI.5122-10.2011.
Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis.
Reisinger E, Bresee C, Neef J, Nair R, Reuter K, Bulankina A, Nouvian R, Koch M, Bückers J, Kastrup L, Roux I, Petit C, Hell SW, Brose N, Rhee JS, Kügler S, Brigande JV, Moser T.

J Mol Biol. 2011 Feb 25;406(3):479-90. doi:10.1016/j.jmb.2010.12.031.
The crystal structure of the C₂A domain of otoferlin reveals an unconventional top loop region.
Helfmann S, Neumann P, Tittmann K, Moser T, Ficner R, Reisinger E.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3053-8. doi:10.1073/pnas.1006946108. Epub 2011 Jan 31.
Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.
Hoon M, Soykan T, Falkenburger B, Hammer M, Patrizi A, Schmidt KF, Sassoè-Pognetto M, Löwel S, Moser T, Taschenberger H, Brose N, Varoqueaux F.

Hum Mol Genet. 2011 Jan 1;20(1):28-39.doi: 10.1093/hmg/ddq429.
The connexin26 S17F mouse mutant represents a model for the human hereditary keratitis-ichthyosis-deafness syndrome.
Schütz M, Auth T, Gehrt A, Bosen F, Körber I, Strenzke N, Moser T, Willecke K.



2006 - 2010

Neuron. 2010 Nov 18;68(4):724-38. doi:10.1016/j.neuron.2010.10.027.
Bassoon and the synaptic ribbon organize Ca²+ channels and vesicles to add release sites and promote refilling.
Frank T, Rutherford MA, Strenzke N, Neef A, Pangršič T, Khimich D, Fejtova A, Gundelfinger ED, Liberman MC, Harke B, Bryan KE, Lee A, Egner A, Riedel D, Moser T.

Curr Opin Otolaryngol Head Neck Surg. 2010 Oct;18(5):441-6. doi:10.1097/MOO.0b013e32833e0586. Review.
Structure and function of cochlear afferent innervation.
Meyer AC, Moser T.

PLoS Genet. 2010 Aug 5;6(8). pii: e1001046. doi:10.1371/journal.pgen.1001046.
A missense mutation in a highly conserved alternate exon of dynamin-1 causes epilepsy in fitful mice.
Boumil RM, Letts VA, Roberts MC, Lenz C, Mahaffey CL, Zhang ZW, Moser T, Frankel WN.

Nat Neurosci. 2010 Jul;13(7):869-76. doi: 10.1038/nn.2578.
Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells.
Pangrsic T, Lasarow L, Reuter K, Takago H, Schwander M, Riedel D, Frank T, Tarantino LM, Bailey JS, Strenzke N, Brose N, Müller U, Reisinger E, Moser T.

J Neurosci. 2010 Jun 2;30(22):7587-97. doi:10.1523/JNEUROSCI.0389-10.2010.
Onset coding is degraded in auditory nerve fibers from mutant mice lacking synaptic ribbons.
Buran BN, Strenzke N, Neef A, Gundelfinger ED, Moser T, Liberman MC.

J Neurosci. 2009 Oct 14;29(41):12802-6. doi: 10.1523/JNEUROSCI.3346-09.2009. Review.
Functional properties of synaptic transmission in primary sense organs.
Singer JH, Glowatzki E, Moser T, Strowbridge BW, Bhandawat V, Sampath AP.

J Neurosci. 2009 Aug 26;29(34):10730-40. doi: 10.1523/JNEUROSCI.1577-09.2009.
The Ca2+ channel subunit beta2 regulates Ca2+ channel abundance and function in inner hair cells and is required for hearing.
Neef J, Gehrt A, Bulankina AV, Meyer AC, Riedel D, Gregg RG, Strenzke N, Moser T.

J Neurosci. 2009 Jun 24;29(25):8039-50. doi:10.1523/JNEUROSCI.0534-09.2009.
Neuroligin 2 controls the maturation of GABAergic synapses and information processing in the retina.
Hoon M, Bauer G, Fritschy JM, Moser T, Falkenburger BH, Varoqueaux F.

J Neurosci. 2009 Jun 24;29(25):7991-8004. doi: 10.1523/JNEUROSCI.0632-09.2009.
Complexin-I is required for high-fidelity transmission at the endbulb of Held auditory synapse.
Strenzke N, Chanda S, Kopp-Scheinpflug C, Khimich D, Reim K, Bulankina AV, Neef A, Wolf F, Brose N, Xu-Friedman MA, Moser T.

BMC Neurosci. 2009 May 29;10:54. doi: 10.1186/1471-2202-10-54.
Does a single session of theta-burst transcranial magnetic stimulation of inferior temporal cortex affect tinnitus perception?
Poreisz C, Paulus W, Moser T, Lang N.

Nat Neurosci. 2009 Apr;12(4):444-53. doi:10.1038/nn.2293.
Tuning of synapse number, structure and function in the cochlea.
Meyer AC, Frank T, Khimich D, Hoch G, Riedel D, Chapochnikov NM, Yarin YM, Harke B, Hell SW, Egner A, Moser T.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4483-8. doi: 10.1073/pnas.0813213106.
Mechanisms contributing to synaptic Ca2+ signals and their heterogeneity in hair cells.
Frank T, Khimich D, Neef A, Moser T.

Am J Hum Genet. 2008 Aug;83(2):278-92. doi:10.1016/j.ajhg.2008.07.008.
Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice.
Ruel J, Emery S, Nouvian R, Bersot T, Amilhon B, Van Rybroek JM, Rebillard G, Lenoir M, Eybalin M, Delprat B, Sivakumaran TA, Giros B, El Mestikawy S, Moser T, Smith RJ, Lesperance MM, Puel JL.

J Physiol. 2007 Dec 15;585(Pt 3):791-803.
Ca2+-binding proteins tune Ca2+-feedback to CaV1.3 channels in mouse auditory hair cells.
Cui G, Meyer AC, Calin-Jageman I, Neef J, Haeseleer F, Moser T, Lee A.

J Neurosci. 2007 Nov 21;27(47):12933-44.
Probing the mechanism of exocytosis at the hair cell ribbon synapse.
Neef A, Khimich D, Pirih P, Riedel D, Wolf F, Moser T.

Neuroscience. 2007 Nov 9;149(3):673-84.
Detection and differentiation of sensorineural hearing loss in mice using auditory steady-state responses and transient auditory brainstem responses.
Pauli-Magnus D, Hoch G, Strenzke N, Anderson S, Jentsch TJ, Moser T.

Pflugers Arch. 2007 May;454(2):335-44.
Measurements of membrane patch capacitance using a software-based lock-in system.
Neef A, Heinemann C, Moser T.

J Neurosci. 2007 Mar 21;27(12):3163-73.
Maturation of ribbon synapses in hair cells is driven by thyroid hormone.
Sendin G, Bulankina AV, Riedel D, Moser T.

Cell Tissue Res. 2006 Nov;326(2):347-59. Review.
Hair cell ribbon synapses.
Moser T, Brandt A, Lysakowski A.

HNO. 2006 Nov;54(11):833-9. Review. German.
Diagnosis and therapy of auditory synaptopathy/neuropathy.
Moser T, Strenzke N, Meyer A, Lesinski-Schiedat A, Lenarz T, Beutner D, Foerst A, Lang-Roth R, von Wedel H, Walger M, Gross M, Keilmann A, Limberger A, Steffens T, Strutz J.

Cell. 2006 Oct 20;127(2):277-89.
Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse.
Roux I, Safieddine S, Nouvian R, Grati M, Simmler MC, Bahloul A, Perfettini I, Le Gall M, Rostaing P, Hamard G, Triller A, Avan P, Moser T, Petit C.

J Physiol. 2006 Oct 1;576(Pt 1):55-62. Epub 2006 Aug 10. Review.
Mechanisms underlying the temporal precision of sound coding at the inner hair cell ribbon synapse.
Moser T, Neef A, Khimich D

Laryngorhinootologie. 2006 Oct;85(10):709-11. German.
Hearing loss -- can heat shock protein 70 be cited as prognostic marker?
Krome S, Moser T, Lenarz T.

Ca2+ channels. Neuroscience. 2006 Sep 15;141(4):1849-60.
Synaptic organization in cochlear inner hair cells deficient for the CaV1.3 (alpha1D) subunit of L-type.
Nemzou N RM, Bulankina AV, Khimich D, Giese A, Moser T.

Glia. 2006 Apr 15;53(6):601-11.
Expression pattern and functional characterization of connexin29 in transgenic mice.
Eiberger J, Kibschull M, Strenzke N, Schober A, Büssow H, Wessig C, Djahed S, Reucher H, Koch DA, Lautermann J, Moser T, Winterhager E, Willecke K.

Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2926-31.
CSPalpha-deficiency causes massive and rapid photoreceptor degeneration.
Schmitz F, Tabares L, Khimich D, Strenzke N, de la Villa-Polo P, Castellano-Muñoz M, Bulankina A, Moser T, Fernández-Chacón R, Südhof TC.

EMBO J. 2006 Feb8;25(3):642-52.
Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness.
Kharkovets T, Dedek K, Maier H, Schweizer M, Khimich D, Nouvian R, Vardanyan V, Leuwer R, Moser T, Jentsch TJ.

J Membr Biol. 2006 Feb-Mar;209(2-3):153-65. Review.
Structure and function of the hair cell ribbon synapse.
Nouvian R, Beutner D, Parsons TD, Moser T.

Neuroscience. 2006;138(2):433-46.
alpha-Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction.
Sons MS, Busche N, Strenzke N, Moser T, Ernsberger U, Mooren FC, Zhang W, Ahmad M, Steffens H, Schomburg ED, Plomp JJ, Missler M.



2001 - 2005

J Neurosci. 2005 Dec 14;25(50):11577-85.
Few CaV1.3 channels regulate the exocytosis of a synaptic vesicle at the hair cell ribbon synapse.
Brandt A, Khimich D, Moser T.

Nature. 2005 Apr 14;434(7035):889-94.
Hair cell synaptic ribbons are essential for synchronous auditory signalling.
Khimich D, Nouvian R, Pujol R, Tom Dieck S, Egner A, Gundelfinger ED, Moser T.

J Neurosci. 2003 Nov 26;23(34):10832-40.
CaV1.3 channels are essential for development and presynaptic activity of cochlear inner hair cells.
Brandt A, Striessnig J, Moser T.

Curr Opin Neurobiol. 2003 Aug;13(4):452-8. Review.
The afferent synapse of cochlear hair cells.
Fuchs PA, Glowatzki E, Moser T.

Nat Neurosci. 2003 Aug;6(8):846-53.
Calcium regulates exocytosis at the level of single vesicles.
Becherer U, Moser T, Stühmer W, Oheim M.

HNO. 2002 May;50(5):415-7. German.
Synaptic function in the auditory pathway and genetics of hearing loss.
Ohlrogge M, Moser T.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11680-5.
Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I.
Voets T, Moser T, Lund PE, Chow RH, Geppert M, Südhof TC, Neher E.

Neuron. 2001 Aug 30;31(4):581-91.
Munc18-1 promotes large dense-core vesicle docking.
Voets T, Toonen RF, Brian EC, de Wit H, Moser T, Rettig J, Südhof TC, Neher E, Verhage M.

J Neurosci. 2001 Jul 1;21(13):4593-9.
The presynaptic function of mouse cochlear inner hair cells during development of hearing.
Beutner D, Moser T.

Neuron. 2001 Mar;29(3):681-90.
Calcium dependence of exocytosis and endocytosis at the cochlear inner hair cell afferent synapse.
Beutner D, Voets T, Neher E, Moser T.



1995 - 2000

J Neurosci. 2000 Nov 15;20(22):8377-83.
The readily releasable pool of vesicles in chromaffin cells is replenished in a temperature-dependent manner and transiently overfills at 37 degrees C.
Dinkelacker V, Voets T, Neher E, Moser T.

J Neurosci. 2000 Nov 15;20(22):8323-30.
R-Type Ca2+ channels are coupled to the rapid component of secretion in mouse adrenal slice chromaffin cells.
Albillos A, Neher E, Moser T.

Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):883-8.
Kinetics of exocytosis and endocytosis at the cochlear inner hair cell afferent synapse of the mouse.
Moser T, Beutner D.

Neuron. 1999 Jul;23(3):607-15.
Mechanisms underlying phasic and sustained secretion in chromaffin cells from mouse adrenal slices.
Voets T, Neher E, Moser T.

Neuron. 1998 Jun;20(6):1243-53.
Cytosolic Ca2+ acts by two separate pathways to modulate the supply of release-competent vesicles in chromaffin cells.
Smith C, Moser T, Xu T, Neher E.

J Physiol. 1998 Jan 1;506 ( Pt 1):195-205.
Low-conductance intercellular coupling between mouse chromaffin cells in situ.
Moser T.

Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6735-40.
Estimation of mean exocytic vesicle capacitance in mouse adrenal chromaffin cells.
Moser T, Neher E.

J Neurosci. 1997 Apr 1;17(7):2314-23.
Rapid exocytosis in single chromaffin cells recorded from mouse adrenal slices.
Moser T, Neher E.

Pflugers Arch. 1995 Dec;431(2):196-203.
Swelling-induced catecholamine secretion recorded from single chromaffin cells.
Moser T, Chow RH, Neher E.