Our publications on optogenetic hearing restoration

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2025

Nat Biomed Eng. 2025 Jul 28. doi: 10.1038/s41551-025-01461-1
Efficient and sustained optogenetic control of sensory and cardiac systems
Alekseev A, Hunniford V, Zerche M, Jeschke M, El May F, Vavakou A, Siegenthaler D, Hüser MA, Kiehn SM, Garrido-Charles A, Meyer A, Rambousky A, Alvanos T, Witzke I, Rojas-Garcia KD, Draband MD, Cyganek L, Klein E, Ruther P, Huet A, Trenholm S, Macé E, Kusch K, Bruegmann T, Wolf BJ, Mager T, Moser T

J Neural Eng. 2025 Jul 15. doi: 10.1088/1741-2552/adf00f
Hearing restoration by a low-weight power-efficient multichannel optogenetic cochlear implant system
Jablonski L, Harczos T, Wolf BJ, Hoch G, Khurana L, Dieter A, Roos L, Hessler R, Ayub S, Ruther P, Moser T

Structure. 2025 Jul 10:S0969-2126(25)00222-9. doi: 10.1016/j.str.2025.06.006
Structural basis for no retinal binding in flotillin-associated rhodopsins
Kovalev K, Stetsenko A, Trunk F, Marin E, Haro-Moreno JM, Lamm GHU, Alekseev A, Rodriguez-Valera F, Schneider TR, Wachtveitl J, Guskov A

Sci Adv. 2025 Jul 4;11(27):eadv1015. doi: 10.1126/sciadv.adv1015
CryoRhodopsins: A comprehensive characterization of a group of microbial rhodopsins from cold environments
Lamm GHU, Marin E, Alekseev A, Schellbach AV, Stetsenko A, Haro-Moreno JM, Bourenkov G, Borshchevskiy V, Asido M, Agthe M, Engilberge S, Rose SL, Caramello N, Royant A, Schneider TR, Bateman A, Mager T, Moser T, Rodriguez-Valera F, Wachtveitl J, Guskov A, Kovalev K

Proc Natl Acad Sci U S A. 2025 May 27; 122(22):e2507582122. doi: 10.1073/pnas.2507582122
Toward elucidating the mechanism of cochlear stimulation by infrared light
Moser T, Roos L

Nat Struct Mol Biol. 2025 Apr 9. doi: 10.1038/s41594-025-01488-7
Ion-conducting and gating molecular mechanisms of channelrhodopsin revealed by true-atomic-resolution structures of open and closed states
Zabelskii D, Bukhdruker S, Bukhalovich S, Tsybrov F, Lamm GHU, Astashkin R, Doroginin D, Matveev G, Sudarev V, Kuzmin A, Zinovev E, Vlasova A, Ryzhykau Y, Ilyinsky N, Gushchin I, Bourenkov G, Alekseev A, Round A, Wachtveitl J, Bamberg E, Gordeliy V

Theranostics. 2025 Mar 18. doi: 10.7150/thno.104474
Improved optogenetic modification of the spiral ganglion neurons for future optical cochlear implants
Thirumalai A, Henseler J, Enayati M, Kusch K, Hessler R, Moser T, Huet AT

2024

Annu Rev Neurosci. 2024 Aug, 47(1):103-121. doi: 10.1146/annurev-neuro-070623-103247
Toward optogenetic hearing restoration
Huet A, Mager T, Gossler C, Moser T

Appl Opt. 2024 Jul 24th, 63, 5876-5885. doi: 10.1364/AO.522367
Microlens arrays for multichannel laser-to-waveguide coupling
Kunze K, Gossler C, Peters V, Keppeler D, Moser T, Schwarz UT

Adv Healthc Mater. 2024 Apr 12th, e2304513. doi: 10.1002/adhm.202304513
Fabrication and characterization of PDMS waveguides for flexible optrodes
Rudmann L, Scholz D, Alt MT, Dieter A, Fiedler E, Moser T, Stieglitz T

Stem Cell Res. 2024 Mar;75:103317. doi: 10.1016/j.scr.2024.103317
Genome engineering of a neuronal specific, optogenetic, induced pluripotent stem cell line
Schmoll KA, Mager T, Tse TP, Alameldeen A, Zimmermann WH, Zafeiriou MP

BioRxi. 2024 Jan 17th. doi: 10.1101/2024.01.15.575777. Preprint
CryoRhodopsins: a comprehensive characterization of a new clade of microbial rhodopsins from cold environments
Lamm GHU, Marin E, Schellbach AV, Stetsenko A, Alekseev A, Bourenkov G, Borshchevskiy V, Asido M, Agthe M, Engilberge S, Rose SL, Caramello N, Royant A, Schneider TR, Bateman A, Mager T, Moser T, Wachtveitl J, Guskov A, Kovalev K

2023

Mol Neurobiol. 2023 Dec 20. doi: 10.1007/s12035-023-03865-z
Light-Driven Sodium Pump as a Potential Tool for the Control of Seizures in Epilepsy
Trofimova AM, Amakhin DV, Postnikova TY, Tiselko VS, Alekseev A, Podoliak E, Gordeliy VI, Chizhov AV, Zaitsev AV

Appl Optics. 2023 Dec 10th, 62(35):9353-9360. doi: 10.1364/AO.505167.
Multichannel laser diode to polymer waveguide array coupling with a double-aspheric lens
Kunze K, Goßler C, Reinhardt M, Schwenzer F, Helke C, Reuter D, Keppeler D, Moser T, Schwarz UT

J Biophotonics. 2023 Nov 29th, e202300358. doi: 10.1002/jbio.202300358, Online ahead of print
Angle-dependent light scattering in tissue phantoms for the case of thin bone layers with predominant forward scattering
Witke T, Kuhn E, Teichert F, Goßler C, Schwarz UT, Thränhardt A

BioRxiv. 2023 Nov 18th, doi: 10.1101/2023.11.17.567544v1. Preprint.
Efficient and sustained optogenetic control of nervous and cardiac systems
Zerche M, Hunniford V, Alekseev A, El May F, Vavakou A, Siegenthaler D, Hueser MA, Kiehn SM, Garrido-Charles A, Alvanos T, Witzke I, Trenholm S, Macé E, Kusch K, Bruegmann T, Wolf BJ, Mager T, Moser T

iScience. 2023 Oct 20th, 26(10), 107725. doi: 10.1016/j.isci.2023.107725
En route to sound coding strategies for optical cochlear implants
Khurana L, Harczos T, Moser T, Jablonski L

Brain Stimul. 2023 Sep 29th, S1935-861X(23)01920-4. doi: 10.1016/j.brs.2023.09.018.
Devising a framework of optogenetic coding in the auditory pathway: insights from auditory midbrain recordings
Michael M, Wolf BJ, Klinge-Strahl A, Jeschke M, Moser T, Dieter A

Mol Ther Methods Clin Dev. 2023 Mar 21st. doi: 10.1016/j.omtm.2023.03.009
Channelrhodopsin fluorescent tag replacement for clinical translation of optogenetic hearing restoration
Zerche M, Wrobel C, Kusch K, Moser T, Mager T

Brain Stimul. 2023 Jan 23rd. doi: 10.1016/j.brs.2023.01.1671
Graded optogenetic activation of the auditory pathway for hearing restorations
Mittring A, Moser T, Huet A

Frontiers in Neuroscience. 2023 Jan 23rd, 17:1105562. doi: 10.3389/fnins.2023.1105562
Patient perspectives on the need for improved hearing rehabilitation: A qualitative survey study of German cochlear implant users
Hunniford V, Kühler R, Wolf B, Daniel Keppeler D, Strenzke N, Moser T

GMS Zeitschrift für Audiologie - Audiological Acoustics. 2023 Jan 20th, Doc01. doi: 10.3205/zaud000027
Mit Lichtstrahlen das Gehör wiederherstellen - Restoring hearing with light
Moser T

2022

Materials (Basel). 2022 December 22nd, 16(1):106. doi: 10.3390/ma16010106
On the fabrication and characterization of polymer-based waveguide probes for use in future optical cochlear implants
Helke C, Reinhardt M, Arnold M, Schwenzer F, Haase M, Wachs M, Goßler C, Götz J, Keppeler D, Wolf B, Schaeper J, Salditt T, Moser T, Schwarz UT, Reuter D

EMBO Molecular Medicine, 2022 August 8th, 14(8):e15798. doi: 10.15252/emmm.202215798
Is there an unmet medical need for improved hearing restoration?
Wolf BJ, Kusch K, Hunniford V, Vona B, Kühler R, Keppeler D, Strenzke N, Moser T

Methods in Molecular Biology. 2022 July 21st, 2501:277-288. doi: 10.1007/978-1-0716-2329-9_13
Electrophysiological characterization of microbial rhodopsins by patch-clamp experiments
Mager T

IEEE Spectrum. Online, 2022 July 18th.
Restoring hearing with beams of light
Moser T

Computational and Structural Biotechnology Journal. 2022 July 6th.
Model-based prediction of optogenetic sound encoding in the human cochlea by future optical cochlear implants
Khurana L, Keppeler D, Jablonski L, Moser T

Journal of the American Chemical Society, 2022 May 18th;144(21):9229-9239. doi: 10.1021/jacs.1c12314
Fast photoswitchable molecular prosthetics control neuronal activity in the cochlea
Garrido-Charles A, Huet A, Matera C, Thirumalai A, Hernondo J, Liebaria A, Moser T, Gorostiza P

Life Science Alliance. 2022 May 5th, 5(8):e202101338. doi: 10.26508/lsa.202101338
Analyzing efficacy, stability and safety of AAV-mediated optogenetic hearing restoration in mice
Bali B, Gruber-Dujardin E, Kusch K, Rankovic V, Moser T

Nature Communications, 2022 March 28th;13:1648. doi: 10.1038/s41467-022-29185-9
Flexible auditory training, psychophysics, and enrichment of common marmosets with an automated, touchscreen-based system
Calapai A, Cabrera-Moreno J, Moser T, Jeschke M

2021

Nature Communications, 2022 February 21st;21;13(1):985. doi: 10.1038/s41467-022-28629-6
Multichannel optogenetics combined with laminar recordings for ultra-controlled neuronal interrogation
Eriksson D, Schneider A, Thirumalai A, Alyahyay M, de la Crompe B, Sharma K, Ruther P, Diester I

bioRxiv, 2021 May 25th
Fast photoswitchable molecular prosthetics control neuronal activity in the cochlea
Garrido-Charles A, Huet A T, Matera C, Thirumalai A, Llebraria A, Moser T, Gorostiza P

EMBO Molecular Medicine, 2021 May 7th EMBO Mol Med (2021)e13391, https://doi.org/10.15252/emmm.202013391
Utility of red-light ultrafast optogenetic stimulation of the auditory pathway
Bali B, Lopez de la Morena D, Mittring A, Mager T, Rankovic V, Huet AT, Moser T

PNAS, 2021 May 4th, 118 (18) e2014472118; https://doi.org/10.1073/pnas.2014472118
Multiscale photonic imaging of the native and implanted cochlea
Keppeler D, Kampshoff C, Thirumalai A, Duque-Afonso CJ, Schaeper J, Quilitz T, Töpperwien M, Vogl C, Hessler R, Meyer A, Salditt T, Moser T

Frontiers in Molecular Neuroscience, 2021 March 11th, https://doi.org/10.3389/fnmol.2021.635897
Developing fast, red-light optogenetic stimulation of spiral ganglion neurons for future optical cochlear implants
Huet AT, Dombrowski T, Rankovic V, Thirumalai A, Moser T



2020

Nature Communications 2020 Nov 11;11(1):5707. doi: 10.1038/s41467-020-19457-7
Viral rhodopsins 1 are an unique family of light-gated cation channels
Zabelski D, Alekseev A, Kovalev K, Rankovic V, Balandin T, Soloviov D, Bratanov D, Saveljeva E, Podolyak E, Vokov D, Vaganova S, Astashkin R, Chizov I, Yutin N, Rulev M, Popov A, Eria-Oliveria A-S, Rokitskay T, Mager T, Antonenko Y, Rosselli R, Armeev G, Shaitan K, Vivaudou M, Büldt G, Rogachev A, Rodriguez-Valera F, Kripchnikov M, Moser T, Offenhäuser A, Willbold D, Koonin E, Bamberg E, Gordeliy V

Methods in Molecular Biology 2021, 2020 Sep 01;2191:261-285. doi: 10.1007/978-1-0716-0830-2_16
Application of targeting-optimized Chronos for stimulation of the auditory pathway
Huet A, Rankovic V

Science Translational Medicine, 2020 Jul 22;Vol. 12, Issue 553, eabb8086. DOI: 10.1126/scitranslmed.abb8086
Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents
Keppeler D, Schwaerzle M, Harczos T, Jablonski L, Dieter A, Wolf B, Ayub S, Vogl C, Wrobel C, Hoch G, Abdellatif K, Jeschke M, Rankovic V, Paul O, Ruther P, Moser T
[abstract] [reprint] [full text]

EMBO Molecular Medicine, 2020 Jun 29;e12387. doi: 10.15252
μLED-based optical cochlear implants for spectrally selective activation of the auditory nerve
Dieter A, Klein E, Keppeler D, Jablonski L, Harczos T, Hoch G, Rankovic V, Paul O, Jeschke M, Ruther P, Moser T

bioRxiv, May 2020, preprint
Hearing restoration by a low-weight power-efficient multichannel optogenetic cochlear implant system
Jablonski L, Harczos T, Wolf B, Hoch G, Dieter A, Hessler R, Ayub S, Ruther P, Moser T

Physiological Reviews, 2020 Jul 6, 100(4):1467-1525. doi: 10.1152/physrev.00035.2019
Emerging approaches for restoration of hearing and vision
Kleinlogel S, Vogl C, Jeschke M, Neef J, Moser T

EMBO Molecular Medicine, 2020 Mar 30. e11618, doi.10.15252/emmm.201911618
Towards the Optical Cochlear Implant: Optogenetic Approaches for Hearing Restoration
Dieter A, Keppeler D, Moser T

Biochemical and Biophysical Research Communications, 2020 Feb 4. pii: S0006-291X(20)30090-5. doi: 10.1016/j.bbrc.2019.12.126
Towards optogenetic approaches for hearing restoration
Moser T, Dieter A



2019

Nature Communications, 2019 Apr 29, 10 1962, doi: 10.1038/s41467-019-09980-7
Near physiological spectral selectivity of cochlear optogenetics
Dieter A, Duque Afonso CJ, Rankovic V, Jeschke M, Moser T



2018

EMBO Journal, 05 Nov 2018, doi: 10.15252/embj.201899649
Ultrafast optogenetic stimulation of the auditory pathway by targeting-optimized Chronos
Keppeler D, Martins Merino R, Lopez de la Morena D, Bali B, Huet AT, Gehrt A, Wrobel C, Subramanian S, Dombrowski T, Wolf F, Rankovic V, Neef A, Moser T

Cold Spring Harbor Laboratory Press, October 15th, 2018, a033225 doi: 10.1101/cshperspect.a033225
Toward the optical cochlear implant
Dombrowski T, Rankovic V, Moser T

Science Translational Medicine 11 Jul 2018: Vol. 10, Issue 449, eaao0540 DOI: 10.1126/scitranslmed.aao0540
Optogenetic stimulation of cochlear neurons activates the auditory pathway and restores auditory-driven behavior in deaf adult gerbils
Wrobel C, Dieter A, Huet A, Keppeler D, Duque-Afonso CJ, Vogl C, Hoch G, Jeschke M, Moser T

Nature Communications 2018 May 1 doi:10.1038/s41467-018-04146-3
High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics
Mager T, Lopez de la Morena D, Senn V, Schlotte J, D´Errico A, Feldbauer K, Wrobel C, Jung S, Bodensiek K, Rankovic V, Browne L, Huet A, Jüttner J, Wood P, Letzkus J, Moser T, Bamberg E

Scientific Reports 8 March 21, 2018.
Propagation-based phase-contrast x-ray tomography of cochlea using a compact synchrotron source
Töpperwien M, Gradl R, Keppeler D, Vassholz M, Meyer A, Hessler R, Achterhold K, Gleich B, Dierolf M, Pfeiffer F, Moser T, Salditt T



2014 - 2017

Curr Opin Neurobiol. 2015 Jan 28;34C:29-36. doi:10.1016/j.conb.2015.01.004. Review.
Optogenetic stimulation of the auditory pathway for research and future prosthetics.
Moser T.

Hear Res. 2015 Jan 16. pii: S0378-5955(15)00008-8. doi:10.1016/j.heares.2015.01.005. Review.
Considering optogenetic stimulation for cochlear implants.
Jeschke M, Moser T.

J Vis Exp. 2014 Oct 8;(92):e52069. doi: 10.3791/52069.
Optogenetic stimulation of the auditory nerve.
Hernandez VH, Gehrt A, Jing Z, Hoch G, Jeschke M, Strenzke N, Moser T.

J Clin Invest. 2014 Mar 3;124(3):1114-29. doi:10.1172/JCI69050.
Optogenetic stimulation of the auditory pathway.
Hernandez VH, Gehrt A, Reuter K, Jing Z, Jeschke M, Mendoza Schulz A, Hoch G, Bartels M, Vogt G, Garnham CW, Yawo H, Fukazawa Y, Augustine GJ, Bamberg E, Kügler S, Salditt T, de Hoz L, Strenzke N, Moser T.