Our publications on otoferlin
2023
Protein Cell, accepted
Ca2+-binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing
Chen H, Monga M, Fang Q, Slitin L, Neef J, Chepurwar SS, Mingroni Netto RC, Lezirovitz K, Tabith A, Benseler F, Brose N, Kusch K, Wichmann C, Strenzke N, Vona B, Preobraschenski J Moser T
BioRxiv. 2023 Mar 10th. doi: 10.1101/2022.08.03.502284. Preprint.
Visualizing proteins by expansion microscopy
Shaib AH, Chouaib AA, Chowdhury R, Mihaylov D, Zhang C, Imani V, Georgiev SV, Mougios N, Monga M, Reshetniak S, Mimoso T, Chen H, Fatehbasharzad P, Crzan D, Saal K-A, Alawar N, Eilts J, Kang J, Alvarez L, Trenkwalder C, Mollenhauer B, Outeiro TF, Köster S, Preobraschenski J, Becherer U, Moser T, Boyden ES, Aricescu AR, Sauer M, Opazo F, Rizzoli SO
2022
2021
Frontiers in Molecular Neuroscience. 2021 January 7th, 13:253. doi: 10.3389/fnmol.2020.600051
Overloaded adeno-associated virus as a novel gene therapeutic tool for otoferlin-related deafness
Rankovic V, Vogl C, Dörje NM, Bahader I, Duque-Afonso CJ, Thirumalai A, Weber T, Kusch K, Strenzke N, Moser T
2020
2019
2018
2016
EMBO J. 2016 Dec 1. 35(23):2519-2535
Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants.
Strenzke N., Chakrabarti R., Al-Moyed H., Müller A., Hoch G., Pangrsic T., Yamanbaeva G., Lenz C., Pan KT., Auge E., Geiss-Friedlander R., Urlaub H., Brose N., Wichmann C., Reisinger E.
EMBO J 2016 Jul 25. doi 10.15252/embj.201593565| The EMBO Journal (2016) e201593565
Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing.
Vogl C., Panou I., Yamanbaeva G., Wichmann C., Mangosing S., Vilardi F., Indzhykulian A., Pangršič T., Santarelli R., Rodriguez-Ballesteros M., Weber T., Jung S., Cardenas E., Wu X., Wojcik S.M., Kwan K.Y., del Castillo I., Schwappach B., Strenzke N., Corey D.P., Lin S.Y., Moser T.
Nat Rev Neurol. 2016 Feb 19. doi: 10.1038/nrneurol.2016.10. [Epub ahead of print]. Review.
Auditory neuropathy - neural and synaptic mechanisms.
Moser T., Starr A.
2015
2014
J Neurosci. 2014 Jan 15;34(3):705-16. doi: 10.1523/JNEUROSCI.3313-13.2014.
Modes and regulation of endocytic membrane retrieval in mouse auditory hair cells.
Neef J, Jung S, Wong AB, Reuter K, Pangrsic T, Chakrabarti R, Kügler S, Lenz C, Nouvian R, Boumil RM, Frankel WN, Wichmann C, Moser T.
2013
2011
J Neurosci. 2011 Mar 30;31(13):4886-95. doi:10.1523/JNEUROSCI.5122-10.2011.
Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis.
Reisinger E, Bresee C, Neef J, Nair R, Reuter K, Bulankina A, Nouvian R, Koch M, Bückers J, Kastrup L, Roux I, Petit C, Hell SW, Brose N, Rhee JS, Kügler S, Brigande JV, Moser T.
2006 - 2010
Nat Neurosci. 2010 Jul;13(7):869-76. doi: 10.1038/nn.2578.
Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells.
Pangrsic T, Lasarow L, Reuter K, Takago H, Schwander M, Riedel D, Frank T, Tarantino LM, Bailey JS, Strenzke N, Brose N, Müller U, Reisinger E, Moser T.